Browsing by Author "XX677246"

Now showing items 1-19 of 19

    • Bioequivalence of Acenocoumarol in Chilean Volunteers: an Open, Randomized, Double-Blind, Single-Dose, ... 
      Sasso Aguirre, Jaime Alfredo; Carmona, P.; Quiñones Sepúlveda, Luis; Ortiz Olcay, Mario; Tamayo Carrillo, Evelyn; Varela Figueroa, Nelson; Cáceres Lillo, Dante; Saavedra Saavedra, Iván (2012)
      The aim of this study was to compare the bioavailability of an oral formulation of the coumarin derivative-vitamine K antagonist acenocoumarol (Acebron TM 4 mg, Test) with the reference formulation (Neo-Sintrom TM 4 ...
    • Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state 
      Videla Cabrera, Luis; Fernández Arancibia, Virginia; Cornejo, Pamela; Vargas, Romina; Carrasco, Juan; Fernández, Javier; Varela Figueroa, Nelson (Elsevier, 2015)
      L-3,3',5-Triiodothyronine (T-3) induced liver oxidative stress underlies significant protein oxidation, which may trigger the unfolded protein response (UPR). Administration of daily doses of 0.1 mg T-3 for three consecutive ...
    • Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through ... 
      Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis; Stojanova, Jana; Garay, Joselyn; Cáceres Lillo, Dante; Céspedes, Silvia; Sasso, Jaime; Miranda, Carla (Elsevier, 2015)
      We tested the influence of four polymorphisms and gene duplication in CYP2D6 on in vivo enzyme activity in a Chilean mestizo population in order to identify the most relevant genetic profiles that account for observed ...
    • Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs ... 
      Roco Arriagada, Angela Margarita; Quiñones Sepúlveda, Luis; Agúndez, José A. G.; García Martin, Elena; Squicciarini Rueda, Valentina; Miranda Melo, Carla Estefanía; Garay, Joselyn; Farfán, Nancy; Saavedra Saavedra, Iván; Cáceres Lillo, Dante; Ibarra, Carol; Varela Figueroa, Nelson (2012)
      Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are ...
    • Functionally significant coumarin-related variant alleles and time to therapeutic range in chilean ... 
      Rojo, Mario; Roco Arriagada, Ángela; Suárez, Marcelo; Lavanderos Villagrán, María Alejandra; Verón, Gabriel; Bertoglia Arredondo, María Paz; Arredondo, Annabella; Nieto, Elena; Rubilar, Juan Carlos; Tamayo, Francisca; Cruz, Daniela; Muñóz, Jessica; Bravo, Gabriela; Salas, Patricio; Mejías, Fanny; Véliz, Paulo; Godoy, Gerald; Varela Figueroa, Nelson; Llull, G.; Quiñones Sepúlveda, Luis (SAGE, 2020)
      Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide. In Chile, the Ministry of ...
    • Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer 
      Escalante, Paula; Barría, Tamara; Cancino Castañeda, Miguel; Rahal Espejo, Maritza; Cerpa, Leslie; Sandoval, Christopher; Molina Mellico, Sebastián; Suárez, Marcelo I.; Martínez, Matías; Cáceres Lillo, Dante; Quiñones, Luis Abel; Varela Figueroa, Nelson (Portland Press, 2020)
      Laryngeal squamous cell carcinoma (LSCC) is a highly disabling disease to the patient, affecting speech, swallowing and respiratory skills. Smoking and alcohol abuse are principal risk factors linked to this disease. Genetic ...
    • Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and ... 
      D’Afonseca, Vívian; Arencibia, Ariel D.; Echeverría Vega, Álex; Cerpa, Leslie; Cayún, Juan P.; Varela Figueroa, Nelson; Salazar, Marcela; Quiñones Sepúlveda, Luis (SAGE, 2020)
      Prognostic markers for cancer can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities. Gallbladder cancer (GBC) is a rare tumor that causes 165 087 ...
    • Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: ... 
      Cáceres Lillo, Dante; Iturrieta G., Jeannette; Acevedo Castillo, Cristián; Huidobro Alvarado, Christian; Varela Figueroa, Nelson; Escala Z., Mario; Quiñones Sepúlveda, Luis (2004)
      Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate ...
    • Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor ... 
      Varela Figueroa, Nelson; Aránguiz Quezada, Katherine Alejandra; Lizama, Carlos; Sepúlveda, Hugo; Antonelli Anativia, Juan; Thaler, Román; Moreno, Ricardo D.; Montecino, Martín; Stein, Gary S.; Van Wijnen, Andre; Galindo Díaz, Mario (Wiley-Blackwell, 2016)
      Epigenetic mechanisms mediate the acquisition of specialized cellular phenotypes during tissue development, maintenance and repair. When phenotype-committed cells transit through mitosis, chromosomal condensation counteracts ...
    • Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients 
      Videla Cabrera, Luis; Rodrigo Salinas, Ramón; Orellana Bown, Myriam; Fernandez, Virginia; Tapia Opazo, Gladys; Quiñones Sepúlveda, Luis; Varela Figueroa, Nelson; Contreras, Jorge; Lazarte, Raúl; Csendes Juhasz, Attila; Rojas Caro, Jorge; Maluenda, Fernando; Burdiles Pinto, Patricio; Díaz Jeraldo, Juan; Smok Sahid, Gladys; Thielemann, Lilian; Poniachik Teller, Jaime (Clinical Science, 2004-03)
      Oxidative stress is implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In the present study, hepatic and plasma oxidative stress-related parameters were measured and correlated with clinical and ...
    • Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y ... 
      Quiñones Sepúlveda, Luis; Rosero P., Mario; Roco Arriagada, Angela Margarita; Moreno T., Iván; Sasso Aguirre, Jaime Alfredo; Varela Figueroa, Nelson; Cáceres Lillo, Dante; Saavedra Saavedra, Iván (Sociedad Médica de Santiago, 2008-10)
      Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy ...
    • Pharmacogenetics-based preliminary model improves prediction of infection in patients receiving cytotoxic ... 
      Martínez, Matías; Alveal, Enzo; Soto, Tomás; Bustamante, Eva; Flores, Ivonne; Araya Benavides, Claudia Andrea; Ávila Oesterle, Fernanda; Jara, Scarlette; Morales, Ricardo; Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis (Wiley, 2020)
    • Pharmacogenomics of antiretroviral therapy in Latin America 
      Varela Figueroa, Nelson; Bernal, Fernando (Nova Science, 2017)
      AIDS is caused by infection with human immunodeficiency virus (HIV), which when untreated produces a critical decline in CD4+ T cells, triggering a progressive dysfunction of the immune system and the development of ...
    • Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a ... 
      González Hormazábal, Patricio; Retamales Ortega, Rocío; Musleh Katan, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raúl; Valladares Hernández, Héctor; Lanzarini Sobrevía, Enrique; Chiong Tello, Héctor; Suazo, José; Quiñones Sepúlveda, Luis; Varela Figueroa, Nelson; Castro, Gonzalo; Jara, Lilian; Verdugo Salgado, Ricardo; Berger, Zoltan (Springer, 2020)
      Genetic variants are considered risk factors for gastric cancer. To date, 61 polymorphisms have been identified as associated with this disease. The aim of the present study was to analyze the association of some of those ...
    • Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: ... 
      Cáceres Lillo, Dante; Iturrieta, Jeannette; Acevedo Castillo, Cristián; Huidobro Alvarado, Christian; Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis (SPRINGER, 2005-01)
      Background: Prostate cancer (PCa) is one of the most common male cancers, but the burden of this disease shows remarkable worldwide variation. The role of susceptibility low penetrance genes and environmental factors in ...
    • Reply to the commentary: Estimating genotype and allele frequencies of the CYP2D6 gene 
      Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis (Academic Press, 2016)
    • Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis ... 
      Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis; Orellana Bown, Myriam; Poniachik Teller, Jaime; Csendes Juhasz, Attila; Smok Sahid, Gladys; Rodrigo Salinas, Ramón; Cáceres Lillo, Dante; Videla Cabrera, Luis (SOC BIOLGIA CHILE, 2008)
      CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene. The aim of this study was to investigate ...
    • The Current state of MicroRNAs as restenosis biomarkers 
      Varela Figueroa, Nelson; Lanas, Fernando; Salazar, Luis; Zambrano Coloma, Tomás (Frontiers Media, 2020)
      In-stent restenosis corresponds to the diameter reduction of coronary vessels following percutaneous coronary intervention (PCI), an invasive procedure in which a stent is deployed into the coronary arteries, producing ...
    • Variantes alélicas de CYP1A1 y GSTM1 como biomarcadores de susceptibilidad a cáncer gástrico: influencia ... 
      Lee, Kuen; Cáceres Lillo, Dante; Varela Figueroa, Nelson; Csendes Juhasz, Attila; Ríos R., Horacio; Quiñones Sepúlveda, Luis (2006)
      Background: Gastric cancer (GaC) is the second cause of death by cancer in the world and one of the first causes in Chile. However, the burden of this disease shows remarkable worldwide variation probably explained by ...