Browsing by Author "XX677248"

Now showing items 1-11 of 11

    • Ca(v)1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression 
      Moreno, Cristian; Hermosilla, Tamara; Hardy, Paulina; Aballai, Víctor; Rojas, Patricio; Varela Lekanda, Diego (MDPI, 2020)
      Functional and morphological modifications in the brain caused by major mood disorders involve many brain areas, including the hippocampus, leading to cognitive and mood alterations. Ca(v)1.2 channel expression has been ...
    • Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the ... 
      Cerda Arancibia, Óscar; Cáceres Lluch, Mónica; Park, Kang-Sik; Leiva Salcedo, Elías; Romero, Aníbal; Varela Lekanda, Diego; Trimmer, James S.; Stutzin Schottlander, Andrés (Springer, 2015)
      Transient receptor potential melastatin-like 4 (TRPM4) is a Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell ...
    • Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor ... 
      Echeverría, César; Montorfano, Ignacio; Hermosilla, Tamara; Armisen Yáñez, Ricardo; Velásquez, Luis A.; Caballero Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (PLOS One, 2014)
      The pathogenesis of systemic inflammatory diseases, including endotoxemia-derived sepsis syndrome, is characterized by endothelial dysfunction. It has been demonstrated that the endotoxin lipopolysaccharide (LPS) induces ...
    • Inhibition of trpm7 protects against inflammatory cytokine overproduction, multiple organ dysfunction, and ... 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Lippincott Williams & Wilkins, 2020)
    • KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis 
      Rivas, José; Díaz, Nicolás; Silva, Ian; Morales, Dana; Lavanderos, Boris; Álvarez, Alhejandra; Saldías Maulén, María Paz; Pulgar Pulgar, Eduardo; Cruz Núñez, Pablo; Maureira, Diego; Flores Utreras, Guillermo; Colombo Flores, Alicia; Blanco, Constanza; Contreras Muñoz, Héctor; Jaña, Fabián; Gallegos Méndez, Iván; Concha Nordemann, Miguel; Vergara Jaque, Ariela; Poblete, Horacio; González, Wendy; Varela Lekanda, Diego; Trimmer, James; Cáceres Lluch, Mónica Andrea; Cerda Arancibia, Óscar (Wiley, 2020)
      Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which ...
    • Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans 
      Simon, Felipe; Varela Lekanda, Diego; Cabello Verrugio, Claudio (Elsevier, 2013)
      The transient receptor potential melastatin (TRPM) protein family is an extensive group of ion channels expressed in several types of mammalian cells. Many studies have shown that these channels are crucial for performing ...
    • P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells 
      Varela Lekanda, Diego; Penna, Antonello; Simon, Felipe; Eguiguren Ossa, Ana; Leiva Salcedo, Elías; Cerda, Oscar; Sala, Francisco; Stutzin Schottlander, Andrés (2010-03-05)
      Volume-sensitive outwardly rectifying (VSOR) Cl channels are critical for the regulatory volume decrease (RVD) response triggered upon cell swelling. Recent evidence indicates that H2O2 plays an essential role in the ...
    • Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced ... 
      Flynn, Robyn; Chapman, Kevin; Iftinca, Mircea; Aboushousha, Reem; Varela Lekanda, Diego; Altier, Christophe (The American Society for Biochemistry and Molecular Biology, 2014)
      The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a polymodal channel activated by noxious ...
    • TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility 
      Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...
    • TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)
      Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...
    • Voltage-Gated K+/Na(+)Channels and Scorpion Venom Toxins in Cancer 
      Díaz García, Alexis; Varela Lekanda, Diego (Frontiers Media, 2020)
      Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, ...