Browsing by Author "a6d2107c-ad1c-4fee-8e20-9f91b0b65299"

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    • Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival 
      Campos, Tania; Ziehe, Javiera; Fuentes Villalobos, Francisco; Riquelme, Orlando; Peña, Daniela; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Morín, Violeta; Pincheira, Roxana; Castro, Ariel F. (Elsevier, 2016)
      Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
    • SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes 
      Hermosilla, Viviana; Salgado, Ginessa; Riffo, Elizabeth; Escobar, David; Hepp, Matias; Farkas, Carlos; Galindo, Mario; Morín, Violeta; García-Robles, María; Castro, Ariel; Pincheira, Roxana (Wiley, 2018-06)
      SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...