Browsing by Author "a6da3aea-1e49-4aa5-91fb-6893bece9547"

Now showing items 1-8 of 8

    • Cloning of hif-1α and hif-2α and mRNA expression pattern during development in zebrafish 
      Rojas, Diego A.; Pérez Munizaga, Daniela A.; Centanin, Lazaro; Antonelli, Marcelo; Wappner, Pablo; Allende Connelly, Miguel; Reyes, Ariel E. (2007)
      Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in vertebrates they are known to participate in several developmental processes, including angiogenesis, vasculogenesis, heart and central ...
    • Dual and opposite roles of reactive oxygen species (ROS) in chagas disease: beneficial on the pathogen and ... 
      Maldonado Maldonado, Edio; Rojas, Diego A.; Morales, Sebastián; Miralles, Vicente; Solari Illescas, Aldo (Hindawi, 2020)
      Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary ...
    • Identification of Ski as a target for Aurora A kinase 
      Mosquera, Jocelyn; Armisen Yáñez, Ricardo; Zhao, Hongling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C.; Colombo, Alicia; Hayman, Michael J.; Marcelain Cubillos, Katherine (2011)
      Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for ...
    • Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways 
      Méndez, Andrea; Rojas, Diego A.; Ponce, Carolina A.; Bustamante, Rebeca; Beltrán, Caroll J.; Toledo, Jorge; García-Angulo, Victor A.; Henriquez, Mauricio; Vargas, Sergio L. (Public Library of Science, 2019)
      Clara cells are the main airway secretory cells able to regenerate epithelium in the distal airways through transdifferentiating into goblet cells, a process under negative regulation of the Notch pathway. Pneumocystis is ...
    • Progression of type 2 helper T celletype inflammation and airway remodeling in a rodent model of naturally ... 
      Iturra, Pablo; Rojas, Diego A.; Pérez, Francisco J.; Méndez, Andrea; Ponce, Carolina A.; Bonilla, Paula; Bustamante, Rebeca; Rodríguez, Héctor; Beltrán, Caroll J.; Vargas, Sergio L. (Elsevier INC, 2018)
      Subclinical primary Pneumocystisinfection is the most common pulmonary infection in early infancy, making it important to determine whether it damages the lung. Pneumocystis peaks at 2 to 5 months of age, when respiratory ...
    • RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal ... 
      Montes, Matías; Moreira Ramos, Sandra; Rojas, Diego A.; Urbina, Fabiola; Käufer, Norbert F.; Maldonado, Edio (Blackwell Publishing Ltd, 2017)
      © 2017 Federation of European Biochemical Societies In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite the importance ...
    • Rrn7 protein, an RNA polymerase I transcription factor, is required for RNA polymerase II-dependent ... 
      Rojas, Diego A.; Moreira-Ramos, Sandra; Zock-Emmenthal, Susanne; Urbina, Fabiola; Contreras-Levicoy, Juan; Käufer, Norbert F.; Maldonado, Edio (2011)
      The region in promoters that specifies the transcription machinery is called the core promoter, displaying core promoter elements (CPE) necessary for establishment of a preinitiation complex and the initiation of transcription. ...
    • Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA ... 
      Contreras-Levicoy, Juan; Moreira-Ramos, Sandra; Rojas, Diego A.; Urbina, Fabiola; Maldonado, Edio (2012)
      TATA box is the most studied core promoter element and has a well-described transcription mechanism. However, most metazoan promoters lack TATA box and contain other core promoter elements. One of such elements is HomolD ...