Browsing by Author "a9c11260-ef89-4234-8b6e-15d1749ad288"
Now showing items 1-13 of 13
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Barbeito, Ana G.; Garringer, Holly J.; Baraibar, Martin A.; Gao, Xiaoying; Arredondo, Miguel; Núñez González, Marco; Smith, Mark A.; Ghetti, Bernardino; Vidal, Ruben (2009)Insertional mutations in exon 4 of the ferritin light chain (FTL) gene are associated with hereditary ferritinopathy (HF) or neuroferritinopathy, an autosomal dominant neurodegenerative disease characterized by progressive ...
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Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo, Miguel; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González, Mauricio (2012)Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
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Gaitán, Diego; Flores, Sebastián; Saavedra, Pía; Miranda, Constanza; Olivares, Manuel; Arredondo, Miguel; López de Romaña, Daniel; Lönnerdal, Bo; Pizarro Aguirre, Fernando (2011)Calcium is the only known component in the diet that may affect absorption of both nonheme and heme iron. However, the evidence for a calcium effect on iron absorption mainly comes from studies that did not isolate the ...
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Latorre, Mauricio; Burkhead, Jason L.; Hodar, Christian; Arredondo, Miguel; González, Mauricio; Araya, Magdalena (Elsevier GmbH, 2019)The independent toxic effects of copper and acetaminophen are among the most studied topics in liver toxicity. Here, in an animal model of Cebus capucinus chronically exposed to high dietary copper, we assessed clinical ...
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Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo, Miguel; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (2008)Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in ...
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Arredondo, Miguel; Muñoz, Patricia; Mura, Casilda; Núñez González, Marco (2003)Despite important advances in the under-standing of copper secretion and excretion, the molecular components of intestinal copper absorption remain a mys-tery. DMT1, also known as Nramp2 and DCT1, is the trans-porter ...
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Cisternas, Felipe A.; Tapia Opazo, Gladys; Arredondo, Miguel; Cartier Ugarte, Denise; Romanque, Pamela; Sierralta, Walter D.; Vial, María T.; Videla Cabrera, Luis; Araya, Magdalena (2005)Cu is an essential trace element capable of producing toxic effects in animals and man when ingested acutely or chronically in excess. Although chronic Cu exposure is increasingly recognized as a public health issue, its ...
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Arredondo, Miguel; Núñez, Héctor; López, Guadalupe; Pizarro Aguirre, Fernando; Ayala, Mariana; Araya, Magdalena (2010)Classic copper indicators are not sensitive and specific for detecting excess copper exposure when this is higher than customary but not markedly elevated. Serum copper and ceruloplasmin (Cp) are the most commonly used ...
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Villarroel, Pia; Le Blanc, Solange; Arredondo, Miguel (2012)Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways. Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear. We studied the modulatory ...
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Espinoza, Alejandra; Le Blanc, Solange; Olivares, Manuel; Pizarro Aguirre, Fernando; Ruz, Manuel; Arredondo, Miguel (2012)Iron (Fe), copper (Cu), and zinc (Zn) fulfill various essential biological functions and are vital for all living organisms. They play important roles in oxygen transport, cell growth and differentiation, neurotransmitter ...
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Arredondo, Miguel; Espinoza, Alejandra; Pizarro Aguirre, Fernando; Araya, Magdalena (2011)Acute and chronic cellular responses to changes in copper availability are not clear when these changes are mild to moderate, as what often occur in human daily life. The aims of the study were to develop an in vitro copper ...
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Gaitán, Diego Alejandro; Flores, Sebastian; Pizarro Aguirre, Fernando; Olivares, Manuel; Suazo, Miriam; Arredondo, Miguel (2012)It has been suggested that calcium inhibits the absorption of dietary iron by directly affecting enterocytes. However, it is not clear if this effect is due to a decreased uptake of iron or its efflux from enterocytes. We ...
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Blanc, Solange Le; Villarroel, Pia; Candia, Valeria; Gavilán, Natalia; Soto, Néstor; Pérez Bravo, Francisco; Arredondo, Miguel (2012)Type 2 diabetes (T2D) is directly related to alterations in iron status, oxidative stress and decreased mitochondrial activity, but the possible interaction of these parameters among T2D patients and their offspring is ...