Browsing by Author "aa29f569-41ca-459f-9876-2d996e75ff61"

Now showing items 1-5 of 5

    • Epigenetic signatures at the RUNX2-P1 and Sp7 gene promoters control osteogenic lineage commitment of ... 
      Sepulveda, Hugo; Aguilar, Rodrigo; Prieto, Catalina P.; Bustos, Francisco; Aedo Monsalve, Sócrates; Lattus Olmos, José; Van Zundert, Brigitte; Palma, Verónica; Montecino, Martín (Wiley, 2017)
      Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent stem cells for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion ...
    • NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, ... 
      Bustos, Fernando J.; Jury, Nur; Martínez, Pablo; Ampuero, Estibaliz; Campos, Matías; Abarzua, Sebastián; Jaramillo, Karen; Ibing, Susanne; Mardones, Muriel D.; Haensgen, Henny; Kzhyshkowska, Julia; Tevy, María Florencia; Neve, Rachael; Sanhueza Toha, María Magdalena; Varela Nallar, Lorena; Montecino, Martín; Van Zundert, Brigitte (Wiley, 2017)
      Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and ...
    • Ski Is required for tri-methylation of H3K9 in major satellite and for repression of pericentromeric genes: ... 
      Cappelli, Claudio; Sepúlveda, Hugo; Rivas Vera, Solange; Pola Véliz, Víctor; Urzúa Tobar, Ulises; Donoso Luna, Gerardo; Sagredo Campos, Eduardo; Carrero Zapata, David; Casanova Ortiz, Emmanuel; Sagredo Campos, Alfredo; González Vergara, Marisel; Manterola Zúñiga, Marcia; Nardocci, Gino; Armisén Yañez, Ricardo; Montecino, Martín; Marcelain Cubillos, Katherine (Elsevier, 2020)
      Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
    • The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells 
      Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
    • Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent ... 
      Jury, Nur; Abarzúa, Sebastián; Díaz, Iván; Guerra, Miguel V.; Ampuero, Estibaliz; Cubillos, Paula; Martínez, Pablo; Herrera Soto, Andrea; Arredondo, Cristian; Rojas, Fabiola; Manterola Zúñiga, Marcia; Rojas, Adriana; Montecino, Martín; Varela Nallar, Lorena; van Zundert, Brigitte (BMC, 2020)
      Background Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...