Browsing by Author "abed0364-6558-4b57-8150-64444adaeb15"

Now showing items 1-7 of 7

    • An intramolecular O-N migration reaction on gold surfaces: Toward the preparation of well-defined amyloid surfaces 
      Boussert, Stephanie; Díez Pérez, Ismael; Kogan Bocian, Marcelo; De Oliveira, Eliandre; Giralt, Ernest (2009)
      Amyloids are a family of self-aggregating proteins implicated in various central nervous system disorders, including Alzheimer's disease (AD). It is thought that prefibrillar soluble forms of amyloid peptides, including ...
    • Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor 
      Prades, Roger; Guerrero, Simón; Araya, Eyleen; Molina, Claudia; Salas, Edison; Zurita, Esther; Selva, Javier; Egea, Gustavo; López-Iglesias, Carmen; Teixidó, Meritxell; Kogan Bocian, Marcelo; Giralt, Ernest (2012)
      The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features ...
    • Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates 
      Bastus, Neus G.; Kogan Bocian, Marcelo; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio; Labarta, Amilcar; Giralt, Ernest; Puntes, Victor F. (2007)
      Nanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle ...
    • Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 
      Velasco Aguirre, Carolina; Morales Zavala, Francisco; Salas Huenuleo, Edison; Gallardo Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan Bocian, Marcelo (Future Medicine, 2017)
      Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials ...
    • Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide 
      Guerrero, Simon; Araya, Eyleen; Fiedler Temer, Jenny; Arias, J.; Adura, Carolina; Albericio, Fernando; Giralt, Ernest; Arias, José; Fernández, María Soledad; Kogan Bocian, Marcelo (2010)
      Background & aims: Gold nanoparticles (GNPs) have promising applications for drug delivery as well as for the diagnosis and treatment of several pathologies, such as those related to the CNS. However, GNPs are retained in ...
    • Peptide multifunctionalized gold nanorods decrease toxicity of beta-amyloid peptide in a Caenorhabditis ... 
      Morales Zavala, Francisco; Arriagada, Hector; Hassan, Natalia; Velasco, Carolina; Riveros Salvatierra, Ana; Álvarez, Alejandra R.; Minniti, Alicia N.; Rojas Silva, Ximena; Munoz, Luis L.; Vásquez Salfate, Rodrigo; Rodríguez, Katherine; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Aldunate, Rebeca; Kogan Bocian, Marcelo (Elsevier, 2017)
      The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene glycols and ...
    • Peptides conjugated to gold nanoparticles induce macrophage activation 
      Bastús, Neus G.; Sánchez-Tilló, Ester; Pujals, Silvia; Farrera, Consol; Kogan Bocian, Marcelo; Giralt, Ernest; Celada, Antonio; Lloberas, Jorge; Puntes, Victor (2009)
      Macrophages that react against pathogenic organisms can also be activated with artificial nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using bone marrow-derived macrophages, here we ...