Browsing by Author "aeb14889-3986-4335-adcf-e7edf4cbb8e0"

Now showing items 1-15 of 15

    • A Molecular stratification of chilean gastric cancer patients with potential clinical applicability 
      Pinto, Mauricio; Córdova Delgado, Miguel; Martínez Retamal, Ignacio; Muñoz Medel, Matías; Bravo, M. Loreto; Duran, Doris; Toledo Villanueva, Francisco Javier; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Koch, Erica; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Owen, Gareth I.; Corvalán, Alejandro H.; Armisén, Ricardo; Garrido, Marcelo (MDPI, 2020)
      Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
    • Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA ... 
      Sotomayor Flores, Cristian; Rivera Mejías, Pablo; Vásquez Trincado, César; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Polakovicova, Iva; Aliaga Tobar, Víctor; García Nannig, Lorena; Roa, Juan Carlos; Rothermel, Beverly A.; Maracaja Coutinho, Vinicius; Ho-Xuan, Hung; Meister, Gunter; Chiong, Mario; Ocaranza, María Paz; Corvalán, Alejandro H.; Parra Ortiz, Valentina; Lavandero González, Sergio (2020)
      Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially ...
    • Clinical, biological and translational significance in gastric cancer of reprimo-like gene, an uncharacterized ... 
      Alarcón, María Alejandra; Olivares, Wilda; Rodríguez, Andrés; Maturana, María José; Bustos, Rocío; Polakovicova, Iva; Córdova Delgado, Miguel; Muñoz Medel, Matías; Garrido, Marcelo; Owen, Gareth; De Mayo, Tomás; Carrasco Aviño, Gonzalo; Amigo, Julio; Riquelme, Arnoldo; González, Robinson; Barrientos, Carlos; Aravena, Edmundo; Villarroel Espíndola, Franz; Corvalán, Alejandro H. (AMER Assoc Cancer Research, 2020)
    • Cohort profile: The Maule cohort (MAUCO) 
      Ferreccio, Catterina; Huidobro, Andrea; Cortés, Sandra; Bambs, Claudia; Toro, Pablo; Van De Wyngard, Vanessa; Acevedo, Johanna; Paredes, Fabio; Venegas, Pía; Verdejo, Hugo; Oyarzún González, Ximena; Cook, Paz; Castro, Pablo F.; Foerster, Claudia; Vargas, Claudio; Koshiol, Jill; Araya, Juan Carlos; Cruz, Francisco; Corvalán, Alejandro H.; Quest, Andrew F.; Kogan, Marcelo J.; Lavandero González, Sergio (Oxford University Press, 2020)
    • Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer 
      Landeros Pérez, Natalia; Santoro, Pablo; Carrasco Aviño, Gonzalo; Corvalán, Alejandro H. (MDPI, 2020)
      The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ...
    • Functional interaction between human papillomavirus type 16 E6 and E7 oncoproteins and cigarette smoke ... 
      Muñoz, Juan Pablo; González, Carolina; Parra, Bárbara; Corvalán, Alejandro H.; Tornesello, Maria Lina; Eizuru, Yoshito; Aguayo, Francisco (2012)
      The smoking habit is the most important, but not a sufficient cause for lung cancer development. Several studies have reported the human papillomavirus type 16 (HPV16) presence and E6 and E7 transcripts expression in lung ...
    • Gold nanoparticle based double‑labeling of melanoma extracellular vesicles to determine the specificity of ... 
      Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis 
      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (WJG Press, 2015)
      © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". ...
    • Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and ... 
      Valenzuela, Manuel; Pérez Pérez, Guillermo; Corvalán, Alejandro H.; Carrasco, Gonzalo; Urra, Hery; Bravo, Denisse; Toledo, Héctor; Quest, Andrew F. G. (2010)
      Helicobacter pylori infects the human stomach and modifies signaling pathways that affect gastric epithelial cell proliferation and viability. Chronic exposure to this pathogen contributes to the onset of gastric atrophy, ...
    • Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer 
      Cerda-Opazo, Paulina; Valenzuela Valderrama, Manuel; Wichmann, Ignacio; Rodríguez, Andrés; Contreras Reyes, Daniel Alberto; Fernández, Elmer A.; Carrasco Aviño, Gonzalo; Corvalán, Alejandro H.; Quest, Andrew F. G. (Impact Journals LLC, 2018)
      © Cerda-Opazo et al. BACKGROUND: The objective of the study was to determine the relationship between Survivin and Reprimo transcript/protein expression levels, and gastric cancer outcome. METHODS: In silico correlations ...
    • Merkel cell polyomavirus in non-small cell lung carcinomas from Chile 
      Gheit, Tarik; Muñoz, Juan Pablo; Levican, Jorge; González, Carolina; Ampuero Llanos, Sandra; Parra, Bárbara; Gaggero Brillouet, Aldo; Corvalán, Alejandro H.; Uribe Meneses, Manuel Ángel; Tommasino, Massimo; Aguayo, Francisco (2012)
      Lung cancer is a leading pathology strongly associated with the smoking habit. However, a viral etiology for a subset of patients developing lung cancer has been suggested. Polyomaviruses (PyVs) are small double stranded ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer 
      Sandoval Borquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Aviño, Gonzalo; Bizama, Carolina; Norero, Enrique; Owen, Gareth I.; Roa, Juan; Corvalán, Alejandro H. (Biomed Central Ltd., 2017)
      Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
    • The phylogeographic diversity of EBV and admixed ancestry in the americas–another model of disrupted ... 
      Corvalán, Alejandro H.; Ruedlinger, Jenny; de Mayo, Tomas; Polakovicova, Iva; González Hormazábal, Patricio; Aguayo, Francisco (MDPI AG, 2019)
      Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in ...
    • The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish 
      Stanic, Karen; Reig, German; Wichmann, Ignacio A.; Opazo, Juan C.; Owen, Gareth I.; Corvalán, Alejandro H.; Concha, Miguel L.; Amigo, Julio D. (Nature Publishing Group, 2019)
      The Reprimo gene family comprises a group of single-exon genes for which their physiological function remains poorly understood. Heretofore, mammalian Reprimo (RPRM) has been described as a putative p53-dependent tumor ...
    • The reprimo-like gene is an epigenetic-mediated tumor suppressor and a candidate biomarker for the non-invasive ... 
      Alarcón, María Alejandra; Olivares, Wilda; Córdova Delgado, Miguel; Muñoz Medel, Matías; Mayo, Tomás de; Carrasco Avino, Gonzalo; Wichmann, Ignacio; Landeros, Natalia; Amigo, Julio; Norero, Enrique; Villarroel Espíndola, Franz; Riquelme, Arnoldo; Garrido, Marcelo; Owen, Gareth; Corvalán, Alejandro H. (MDPI, 2020)
      Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML ...