Browsing by Author "af928ec5-92e1-4586-a71c-b507088b25d6"

Now showing items 1-5 of 5

Artículo

Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived ...

Paris Pizarro, Irmgard; Pérez Pastene, Carolina; Cárdenas, Sergio; Iturra, Patricio; Muñoz, Patricia; Couve, Eduardo; Caviedes Fernández, Pablo; Segura Aguilar, Juan (SPRINGER, 2010-01-20)

Abstract In previous studies, we observed that cells treated with aminochrome obtained by oxidizing dopamine with oxidizing agents dramatically changed cell morphology, thus posing the question if such morphological changes ...
Artículo

Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line

Paris Pizarro, Irmgard; Muñoz, Patricia; Huenchuguala, Sandro; Couve, Eduardo; Sanders, Laurie H.; Greenamyre, John Timothy; Caviedes, Pablo; Segura Aguilar, Juan (2011)

Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
Artículo

Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down ...

Cárdenas, Ana María; Arriagada, Christian; Allen, David D.; Caviedes, Raúl; Cortes, José F.; Martin, José; Couve, Eduardo; Rapoport, Stanley I.; Shimahara, Takeshi; Caviedes, Pablo (Academic Press Inc., 2002)

We have established hippocampal cell lines from normal and trisomy 16 fetal mice, a model of human trisomy 21. Both cell lines, named H1b (derived from a normal animal) and HTk (trisomic) possess neuronal markers by ...
Artículo

Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in ...

Paris Pizarro, Irmgard; Pérez Pastene, Carolina; Cárdenas, Sergio; Iturriaga-Vásquez, Patricio; Muñoz, Patricia; Couve, Eduardo; Caviedes, Pablo; Segura Aguilar, Juan (Springer New York LLC, 2010)
Artículo

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy ...

Huenchuguala, Sandro; Muñoz, Patricia; Zavala, Patricio; Villa, Mónica; Urriola Cuevas, Carlos; Ahumada, Ulises; Graumann, Rebecca; Nore, Beston F.; Couve, Eduardo; Mannervik, Bengt; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Taylor and Francis Inc., 2014)

U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...