Now showing items 1-19 of 19

    • Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Giussani, Dino A.; Riquelme, Raquel A.; Moraga, Fernando A.; McGarrigle, Hugh H.G.; Gaete, Cristián R.; Sanhueza, Emilia M.; Hanson, Mark A.; Llanos Mansilla, Jorge (1996)
      We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the distribution of the ...
    • Giussani, Dino A.; Camm, Emily J.; Niu, Youguo; Richter, Hans G.; Blanco, Carlos E.; Gottschalk, Rachel; Blake, E. Zachary; Horder, Katy A.; Thakor, Avnesh S.; Hansell, Jeremy A.; Kane, Andrew D.; Wooding, F. B.Peter; Cross, Christine M.; Herrera, Emilio A. (2012)
      Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding ...
    • Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Kane, Andrew D.; Niu, Youguo; Herrera, Emilio A.; Morton, A. Jennifer; Giussani, Dino A. (Nature Publishing Group, 2016)
      © 2016, Nature Publishing Group. All rights reserved. Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular ...
    • Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Kane, Andrew D.; Camm, Emily J.; Richter, Hans G.; Lusby, Ciara; Tijsseling, Deodata; Kaandorp, Joepe J.; Derks, Jan B.; Ozanne, Susan E.; Giussani, Dino A. (American Physiological Society, 2013)
      © 2013 The Authors. Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an ...
    • Thakor, Avnesh S.; Herrera, Emilio A.; Serón Ferré, María; Giussani, Dino A. (2010)
      Inadequate umbilical blood flow leads to intrauterine growth restriction, a major killer in perinatal medicine today. Nitric oxide (NO) is important in the maintenance of umbilical blood flow, and antioxidants increase NO ...
    • Cindrova-Davies, Tereza; Herrera, Emilio A.; Niu, Youguo; Kingdom, John; Giussani, Dino A.; Burton, Graham J. (2013)
      Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the ...
    • Llanos Mansilla, Jorge; Riquelme, Raquel A.; Sanhueza, Emilia M.; Herrera Videla, Emilio; Cabello, Gertrudis; Giussani, Dino A.; Parer, Julian T. (2002)
      Unlike fetal animals of lowland species, the llama fetus does not increase its cerebral blood flow during an episode of acute hypoxaemia. This study tested the hypothesis that the fetal llama brain maintains cerebral ...
    • Moraga, Fernando A.; Reyes, Roberto V.; Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Pulgar, Víctor M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2011)
      Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
    • Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • Sanhueza, Emilia M.; Johansen-Bibby, Anja A.; Fletcher, A. J W; Riquelme, Raquel A.; Daniels, Alejandro J.; Serón Ferré, María; Gaete, Cristián R.; Carrasco, Jorge E.; Llanos Mansilla, Jorge; Giussani, Dino A. (2003)
      This study investigated the role of neuropeptide Y (NPY) in mediating cardiovascular responses to reduced oxygenation in the late gestation ovine fetus by: (1) comparing the effects on the cardiovascular system of an ...
    • Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...
    • Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Kane, Andrew D.; Herrera Videla, Emilio; Botting, Kimberley J.; Cross, Christine M.; Itani, Nozomi; Skeffington, Katie L.; Giussani, Dino A. (Sage Pubications INC, 2018)
    • Kane, Andrew D.; Hansell, Jeremy A.; Herrera, Emilio A.; Allison, Beth J.; Niu, Youguo; Brain, Kirsty L.; Kaandorp, Joepe J.; Derks, Jan B.; Giussani, Dino A. (2014)
      Hypoxia is a common challenge to the fetus, promoting a physiological defence to redistribute blood flow towards the brain and away from peripheral circulations. During acute hypoxia, reactive oxygen species (ROS) interact ...