Browsing by Author "b2060fdc-fa7d-4370-aa68-f248eb3913c3"
Now showing items 1-11 of 11
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Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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Parra, Eduardo; Ferreira Parker, Jorge; Gutiérrez, Luis (Spandidos Publ, 2014)Early growth response-1 (Egr-1) and the non-receptor protein tyrosine kinase (c-Abl) are 2 response genes that can act as regulators of cell growth and apoptosis in response to stress. Both Egr-1 and c-Abl regulate cell ...
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Peredo Silva, Liliana; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Pavani Costa, Mario; Maya Arango, Juan; Castro Castillo, Vicente; Madrid Rojas, Matías; Rebolledo, Solange; Kemmerling Weis, Ulrike; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2017)We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
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Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (2013)The p21Waf1/Cip1 protein (hereafter, p21) and the c‑Jun N-terminal kinase (JNK) are two well-characterized cell modulators that play a crucial role in cell differentiation, senescence and apoptosis. Here, we report that ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2015)Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
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Parra, Eduardo; Ferreira, Jorge; Sáenz Iturriaga, Leonardo Enrique (2011)Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...
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Parra, Eduardo; Ferreira, Jorge (2013)Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the ...
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Jara Sandoval, José Antonio; Rojas Rivera, Diego; Castro Castillo, Vicente; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Parra, Eduardo; Pavani, Mario; Maya Arango, Juan Diego; Ferreira Parker, Jorge; Catalán Díaz, Mabel (Elsevier, 2020)Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
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Inostroza, Juan; Sáenz Iturriaga, Leonardo Enrique; Calaf, Gloria; Cabello, Gertrudis; Parra, Eduardo (Society of Biology of Chile, 2005)The specific signaling connections between the mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK-1) and phosphatases PP4 and M3/6, affecting the family of early nuclear factors, is complex and ...
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Parra, Eduardo; Ferreira, Jorge (2010)We have examined the effects of a siRNA targeting the Egr-1, alone or in combination with the breast cancer therapeutic camptothecin (Cpt), in suppressing breast cancer cell survival and anchorage-independent growth in the ...