Browsing by Author "b2072e88-a463-4f64-92d9-9e8925aed616"

Now showing items 1-5 of 5

    • Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction ... 
      Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes ... 
      Olmedo Alegría, Ivonne; Pino Tapia, Gonzalo; Riquelme Meléndez, Jaime; Aranguiz, Pablo; Díaz, Magda C.; López Crisosto, Camila; Lavandero González, Sergio; Donoso Laurent, Paulina; Pedrozo Cibils, Zully; Sánchez Vergara, Gina (Elsevier, 2020)
      Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. ...
    • Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with ... 
      Bejarano, Julián; Rojas, Aldo; Ramírez Sagredo, Andrea; Riveros Salvatierra, Ana; Morales Zavala, Francisco; Flores, Yvo; Riquelme Meléndez, Jaime; Guzmán, Fanny; Araya, Eyleen; Chiong Lay, Mario; Ocaranza, María Paz; Morales Montecinos, Javier; Villamizar Sarmiento, María Gabriela; Sánchez Vergara, Gina; Lavandero González, Sergio; Kogan, Marcelo J. (Elsevier, 2020)
      Angiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled ...
    • Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes 
      Conejeros, Carolina; Parra Ortiz, Valentina; Sánchez Vergara, Gina; Pedrozo Cibils, Zully; Olmedo Alegría, Ivonne (Elsevier, 2020)
      Cardiac hypertrophy is an adaptive response to manage an excessive cardiac workload and maintain normal cardiac function. However, sustained hypertrophy leads to cardiomyopathy, cardiac failure, and death. Adrenergic ...
    • N-Methyl-d-Aspartate receptor modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase type 2 ... 
      Plaza Briceño, Wladimir; Estay, Sebastián; Fuente Ortega, Erwin de la; Gutiérrez, Camilo; Sánchez Vergara, Gina; Hidalgo Tapia, María Cecilia; Chávez, Andrés; Haeger, Paola (Mary Ann Liebert, 2020)
      Aims: Pre- and/or early postnatal ethanol exposure (prenatal alcohol exposure [PAE]) impairs synaptic plasticity as well as memory formation, but the mechanisms underlying these effects remain unclear. Both long-term ...