Browsing by Author "b2ac562a-87b2-47b8-ac48-20290fbb6d81"

Now showing items 1-4 of 4

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA ... 
      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 
      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response 
      Dufey, Estefanie; Bravo San Pedro, José; Eggers Aracena, Cristián; González Quiroz, Matías; Urra Zúñiga, Hery; Sagredo Campos, Alfredo; Sepúlveda Alvarado, Denisse; Pihán Najle, Philippe; Carreras Sureda, Armando; Hazari, Younis; Sagredo, Eduardo A.; Gutiérrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Rémy; Chevet, Eric; Álvarez, Alejandra R.; Godoy, Patricio; Walter, Peter; Glavic Maurer, Álvaro; Kroemer, Guido; Hetz Flores, Claudio (Nature, 2020)
      The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1 ...
    • Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma 
      Espinoza, Jaime A.; Riquelme, Ismael; Sagredo, Eduardo A.; Rosa, Lorena; García, Patricia; Bizama, Carolina; Apud-Bell, María; Leal, Pamela; Weber, Helga; Benavente, Felipe; Vargas, Sergio; Romero, Diego; Kalergis, Alexis M.; Roa, Juan Carlos (Blackwell Publishing Ltd, 2019)
      Aims: Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels ...