Browsing by Author "b2bc5324-2ac4-48af-a24e-b220015debad"

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    • Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease 
      Herrera, Andrea; Muñoz Tapia, Patricia; Paris Pizarro, Irmgard; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Inzunza, José; Hultenby, Kjell; Cárdenas Matus, Julio; Jaña Prado, Fabián; Raisman Vozari, Rita; Gysling, Katia; Abarca, Jorge; Steinbusch, Harry; Segura Aguilar, Juan (Springer, 2016)
      L-Dopa continues to be the gold drug in Parkinson's disease ( PD) treatment from 1967. The failure to translate successful results from preclinical to clinical studies can be explained by the use of preclinical models which ...
    • The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores ... 
      Huenchuguala Peralta, Sandro; Muñoz Tapia, Patricia; Segura Aguilar, Juan (American Chemical Society, 2017)
      Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...