Browsing by Author "b301968e-de4e-4a04-8600-a982a9ccb473"

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    • Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways 
      Osorio, Fabiola; Lambrecht, Bart; Janssens, Sophie (Elsevier, 2018-06)
      The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become ...
    • Regulated Inositol Requiring Enzyme 1 dependent mRNA decay sets the threshold for dendritic cell survival 
      Tavernier, Simon J.; Osorio Olivares, Fabiola; Vandersarren, Lana; Vetters, Jessica; Vanlangenakke, Nele; Van Isterdael, Gert; Vergote, Karl; De Rycke, Riet; Parthoens, Eef; van de Laar, Lianne; Iwawaki, Takao; Valle, Juan R. del; Hu, Chih-Chi Andrew; Lambrecht, Bart N.; Janssens, Sophie (Nature Publishing Group, 2017)
      The IRE1/XBP1 signaling pathway is part of a cellular program that protects from endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional ...