Browsing by Author "b5991a02-b099-432a-9669-89cb6ab06743"
Now showing items 1-4 of 4
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Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
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Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka; Pardo, Evelyn; Molgό, Jordi; Cárdenas, César (Taylor and Francis Inc., 2019)© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent ...
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Pérez Moreno, Pablo; Quezada Meza, Camila; Chávez Almarza, Cristopher; Niechi, Ignacio; Silva Pavez, Eduardo; Trigo Hidalgo, César; Aguayo González, Francisco; Jara Sosa, Lilian; Cáceres Verschae, Albano; Varas Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Verónica A.; Tapia Pineda, Julio (Frontiers Media, 2020)Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ...
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Silva Pavez, Eduardo; Tapia Pineda, Julio (Frontiers Media, 2020)Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...