Now showing items 1-6 of 6

    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Álvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J.M.; Hetz Flores, Claudio (Springer Verlag, 2017)
      © 2017, Springer-Verlag Berlin Heidelberg. Altered proteostasis is a salient feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress ...
    • Medel, Bernardita; Costoya, Cristobal; Fernandez, Dominique; Pereda, Cristian; Lladser, Alvaro; Sauma, Daniela; Pacheco, Rodrigo; Iwawaki, Takao; Salazar Onfray, Flavio; Osorio, Fabiola (Frontiers Media S.A., 2019)
      The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator ...
    • Tavernier, Simon J.; Osorio Olivares, Fabiola; Vandersarren, Lana; Vetters, Jessica; Vanlangenakke, Nele; Van Isterdael, Gert; Vergote, Karl; De Rycke, Riet; Parthoens, Eef; van de Laar, Lianne; Iwawaki, Takao; Valle, Juan R. del; Hu, Chih-Chi Andrew; Lambrecht, Bart N.; Janssens, Sophie (Nature Publishing Group, 2017)
      The IRE1/XBP1 signaling pathway is part of a cellular program that protects from endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional ...
    • Tavernier, Simon J.; Osorio, Fabiola; Vandersarren, Lana; Vetters, Jessica; Vanlangenakker, Nele; Van Isterdael, Gert; Vergote, Karl; De Rycke, Riet; Parthoens, Eef; Van De Laar, Lianne; Iwawaki, Takao; Del Valle, Juan R.; Hu, Chih Chi Andrew; Lambrecht, Bart N.; Janss (Nature Publishing Group, 2017)
      © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls ...