Browsing by Author "b634b2ee-0cdb-47c7-b585-8a9753478332"
Now showing items 1-13 of 13
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(BioMed Central, 2014)Background: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic ...
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(2016)Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. ...
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(1994)An ELISA to detect circulating antibodies against K99 pili, a major attachment factor to intestinal epithelial cells of Escherichia coli in calves, was performed. Two methods of K99 pili purification were attempted. Best ...
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(AMER ASSOC CANCER RESEARCH, 2011-04-15)Purpose: This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen–presenting cells (TAPCells). In particular, we identified factors ...
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Human survivin and trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo (2014)Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth ...
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(PLOS Neglected Tropical Diseases, 2013)Background: 9 million people are infected with Trypanosoma cruzi in Latin America, plus more than 300,000 in the United States, Canada, Europe, Australia, and Japan. Approximately 30% of infected individuals develop ...
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(Frontiers Media, 2016)Eight to 10 million people in 21 endemic countries are infected with Trypanosoma cruzi. However, only 30% of those infected develop symptoms of Chagas' disease, a chronic, neglected tropical disease worldwide. Similar to ...
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(2007)Current knowledge of the biochemistry of Trypanosonta cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through ...
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Parasite calreticulins: Structure, C1q binding and dual carbohydrate/peptide interaction properties (2016)Calreticulin (CRT) is a multifaceted protein of 45k Da, early discovered as a receptor of the collagen-like regions of the complement C1q protein and better known as an ER chaperone protein, essential in calcium metabolism. ...
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(Elsevier, 2020)Microbes have developed mechanisms to resist the host immune defenses and some elicit antitumor immune responses. About 6 million people are infected with Trypanosoma cruzi, the protozoan agent of Chagas' disease, the sixth ...
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(Elsevier, 2020)To successfully infect, Trypanosome cruzi evades and modulates the host immune response. T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER)-resident chaperone that, translocated to the external ...
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(Frontiers media SA, 2017)American Trypanosomiasis is an important neglected reemerging tropical parasitism, infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple mechanisms to evade the host immune response ...
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(Biomed Central Ltd., 2017)Brucella canis is a small intracellular Gram-negative bacterium whose primary host is the dog, but it also can cause mild human brucellosis. One of the main causes of an inefficient immune response against other species ...
