Now showing items 1-16 of 16

    • Israel Jacard, Yedy; Karahanian, Eduardo; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Quintanilla González, María Elena (Frontiers Media S.A., 2017)
      © 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
    • Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Lespay Rebolledo, Carolyne; Herrera Marschitz, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2019)
      © 2017 Society for the Study of Addiction Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells ...
    • Ezquer, Fernando; Bahamonde, Javiera; Huang, Ya Lin; Ezquer, Marcelo (BioMed Central Ltd., 2017)
      © 2017 The Author(s). Background: The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis ...
    • Quintanilla González, María Elena; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)
      © 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
    • Lobos González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomón, Carlos; Varas Godoy, Manuel; Cáceres Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica A.; Villegas, Jaime (Nature, 2020)
      During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
    • Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)
      Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
    • De Gregorio, Cristián; Contador, David; Díaz, Diego; Cárcamo, Constanza; Santapau, Daniela; Lobos González, Lorena; Acosta, Cristián; Campero Soffia, Mario; Carpio, Daniel; Gabriele, Caterina; Gaspari, Marco; Aliaga Tobar, Víctor; Maracaja Coutinho, Vinicius; Ezquer, Marcelo; Ezquer, Fernando (BMC, 2020)
      Background Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available. Different studies ...
    • Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Wiley, 2020)
    • Encina, Gonzalo; Ezquer, Fernando; Conget, Paulette; Israel Jacard, Yedy (2011)
      Transgenic mice carrying the human insulin gene driven by the K-cell glucose-dependent insulinotropic peptide (GIP) promoter secrete insulin and display normal glucose tolerance tests after their pancreatic β-cells have ...
    • Israel Jacard, Yedy; Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario (2017)
      © The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved. Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats ...
    • Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia Bustos, Andrea; Quintanilla González, María; Ezquer, Fernando; Valdés, José Luis; Israel Jacard, Yedy; Herrera Marschitz, Mario; Morales Retamales, Eugenia (2020)
      Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
    • Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan Bocian, Marcelo; Salas Huenuleo, Edison; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)
      © 2018 Society for the Study of AddictionChronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that ...
    • Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature Publishing Group, 2018)
      Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
    • Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature, 2018)
      Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
    • Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Olivares, Belén; Santapau, Daniela; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Frontiers Media, 2020)
      Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in ...
    • Berrios Cárcamo, Pablo; Quezada, Mauricio; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2020)
      Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...