Browsing by Author "b6df5a0f-db5e-416b-b07c-56ce9c6aa560"

Now showing items 1-14 of 14

    • Acquisition, maintenance and relapse-like alcohol drinking: Lessons from the uchb rat line 
      Israel Jacard, Yedy; Karahanian, Eduardo; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Quintanilla González, María Elena (Frontiers Media S.A., 2017)
      © 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
    • Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like ... 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Lespay Rebolledo, Carolyne; Herrera Marschitz, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2019)
      © 2017 Society for the Study of Addiction Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells ...
    • Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver ... 
      Ezquer, Fernando; Bahamonde, Javiera; Huang, Ya Lin; Ezquer, Marcelo (BioMed Central Ltd., 2017)
      © 2017 The Author(s). Background: The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis ...
    • Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by ... 
      Quintanilla González, María Elena; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)
      © 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
    • Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast ... 
      Lobos González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomón, Carlos; Varas Godoy, Manuel; Cáceres Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica A.; Villegas, Jaime (Nature, 2020)
      During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
    • Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational ... 
      Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)
      Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
    • Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration ... 
      De Gregorio, Cristián; Contador, David; Díaz, Diego; Cárcamo, Constanza; Santapau, Daniela; Lobos González, Lorena; Acosta, Cristián; Campero Soffia, Mario; Carpio, Daniel; Gabriele, Caterina; Gaspari, Marco; Aliaga Tobar, Víctor; Maracaja Coutinho, Vinicius; Ezquer, Marcelo; Ezquer, Fernando (BMC, 2020)
      Background Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available. Different studies ...
    • Innate gut microbiota is required for the acquisition of ethanol intake and relapse binge‐drinking by ... 
      Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Wiley, 2020)
    • Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells ... 
      Encina, Gonzalo; Ezquer, Fernando; Conget, Paulette; Israel Jacard, Yedy (2011)
      Transgenic mice carrying the human insulin gene driven by the K-cell glucose-dependent insulinotropic peptide (GIP) promoter secrete insulin and display normal glucose tolerance tests after their pancreatic β-cells have ...
    • Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats 
      Israel Jacard, Yedy; Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario (2017)
      © The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved. Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats ...
    • Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, ... 
      Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia Bustos, Andrea; Quintanilla González, María; Ezquer, Fernando; Valdés, José Luis; Israel Jacard, Yedy; Herrera Marschitz, Mario; Morales Retamales, Eugenia (2020)
      Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
    • Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ... 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan Bocian, Marcelo; Salas Huenuleo, Edison; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)
      © 2018 Society for the Study of AddictionChronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that ...
    • N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection 
      Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Olivares, Belén; Santapau, Daniela; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Frontiers Media, 2020)
      Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in ...
    • Oxidative stress and neuroinflammation as a pivot in drug abuse. A focus on the therapeutic potential of ... 
      Berrios Cárcamo, Pablo; Quezada, Mauricio; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2020)
      Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...