Browsing by Author "b7094bf7-102d-4d35-bea9-88c095f895fe"

Now showing items 1-3 of 3

    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 
      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Lack of pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice 
      Gajardo, Ivana; Salazar, Claudia S.; López Espindola, Daniela; Estay, Carolina; Flores Muñoz, Carolina; Elgueta, Claudio; González Jamett, Arlek M.; Martinez, Agustin D.; Muñoz, Pablo; Ardiles, Alvaro O. (Frontiers media SA, 2018)
      Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation. Although LTP has received considerable more attention, ...