Browsing by Author "b9afadc7-49df-4b25-bdd6-2158ef748d1a"
Now showing items 1-9 of 9
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Saldías, María Paz; Fernández, Christian; Morgan, Alejandra; Díaz, Catalina; Morales, Diego; Jana, Fabian; Gómez Gallo, Alvaro; Silva, Alonso; Briceño, Fernanda; Oyarzún, Alejandro; Maldonado Caniulao, Felipe; Cerda Arancibia, Óscar; Smith, Patricio C.; Cáceres, Mónica (Public Library Science, 2017)Aging is a gradual biological process characterized by a decrease in cell and organism functions. Gingival wound healing is one of the impaired processes found in old rats. Here, we studied the in vivo wound healing process ...
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Tobar, Nicola´s; Toyos, Marcela; Urra, Carla; Me´ndez, Nicola´s; Arancibia, Rodrigo; Smith, Patricio C.; Marti´nez, Jorge (BioMed Central Ltd., 2014)© 2014 Tobar et al.; licensee BioMed Central Ltd. Background: Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading ...
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Retamal, Ignacio; Hernández, Romina; Velarde, Victoria; Oyarzún, Alejandro; Martínez, Constanza; González Burgos, María Julieta; Martínez Winkler, Jorge; Smith, Patricio C. (Wiley, 2020)Objectives Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of ...
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Kallens, Violeta; Tobar Bachler, Nicolás; Molina, Jessica; Bidegain, Arantzazú; Smith, Patricio C.; Porras Espinoza, Omar; Martínez, Jorge (Wiley, 2017)Chronic inflammation and metabolic reprogramming have been proposed as hallmarks of cancer development. Currently, many of the functional clues between these two phenomena are studied under the integrative view of functional ...
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Smith, Patricio C.; Cáceres, Mónica; Martinez, Jorge (2006)Background and Objectives: Myofibroblastic differentiation is an important event in gingival wound healing and chronic inflammation. Transforming frowth factor-β 1 (TGF-β1) is a potent growth factor that has been implicated ...
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Tobar Bachler, Nicolás; Porras Espinoza, Omar; Smith, Patricio C.; Barros, L. Felipe; Martínez, Jorge (Wiley, 2017)Hyperglycemia is a risk factor for a variety of human cancers. Increased access to glucose and that tumor metabolize glucose by a glycolyticprocess even in the presence of oxygen (Warburg effect), provide a framework to ...
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Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar, Paula; Dotor, Javier; Smith, Patricio C.; Martínez, Jorge (2010)In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic ...
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Martínez Winkler, Jorge; Smith, Patricio C. (MDPI, 2021)Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation ...
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Páez, Jassir; Hernández, Romina; Espinoza, Javier; Rojas, Leticia; Martínez, Constanza E.; Tobar Bachler, Nicolás; Martínez Winkler, Jorge; Smith, Patricio C. (Wiley, 2020)Background and objective: Aging is characterized by a decline in tissue structure and function that may be explained by the development of cellular senescence. However, the acquisition of specific phenotypic responses in ...