Browsing by Author "bdd51f53-e5ea-486f-ac7f-881b80542f19"

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    • A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice 
      Acuña, Aníbal I.; Esparza, Magdalena; Kramm, Carlos; Beltrán, Felipe A.; Parra, Alejandra V.; Cepeda, Carlos; Toro, Carlos A.; Vidal, René L.; Hetz Flores, Claudio; Concha, Ilona I.; Brauchi, Sebastián; Levine, Michael S.; Castro, Maite A. (Nature Publishing Group, 2013)
      Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal ...
    • Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol 
      Pérez, Alejandra; Ojeda, Paola; Valenzuela, Ximena; Ortega, Marcela; Sánchez, Claudio; Ojeda, Lorena; Castro, Maite; Cárcamo, Juan G.; Rauch, M. Cecilia; Concha, Ilona I.; Rivas, Coralia I.; Vera, Juan C.; Reyes, Alejandro M. (2009)
      Gossypol is a natural disesquiterpene that blocks the activity of the mammalian facilitative hexose transporter GLUT1. In human HL-60 cells, which express GLUT1, Chinese hamster ovary cells overexpressing GLUT1, and human ...
    • Interleukin-3 prevents neuronal death induced by amyloid peptide 
      Zambrano, Angara; Otth, Carola; Mujica, Lorena; Concha, Ilona I.; Maccioni Baraona, Ricardo (BIOMED CENTRAL LTD, 2007-10-03)
      Background: Interleukin-3 (IL-3) is an important glycoprotein involved in regulating biological responses such as cell proliferation, survival and differentiation. Its effects are mediated via interaction with cell surface ...
    • Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors 
      Vidal, René L.; Ramírez, Alfredo; Castro, Maite; Concha, Ilona I.; Couve, Andrés (2008)
      Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression ...
    • The protein kinase cdk5: Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology 
      Maccioni Baraona, Ricardo; Otth, Carola; Concha, Ilona I.; Muñoz, Juan P. (2001)
      A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3b (GSK3b), MARK kinase, MAP kinase, the cyclin-dependent kinase 5 (Cdk5) system and others. The latter ...