Browsing by Author "bddc31f0-9427-4dcd-b8b2-7445fd1fb02a"

Now showing items 1-4 of 4

    • Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease 
      Herrera, Andrea; Muñoz Tapia, Patricia; Paris Pizarro, Irmgard; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Inzunza, José; Hultenby, Kjell; Cárdenas Matus, Julio; Jaña Prado, Fabián; Raisman Vozari, Rita; Gysling, Katia; Abarca, Jorge; Steinbusch, Harry; Segura Aguilar, Juan (Springer, 2016)
      L-Dopa continues to be the gold drug in Parkinson's disease ( PD) treatment from 1967. The failure to translate successful results from preclinical to clinical studies can be explained by the use of preclinical models which ...
    • Analgesic and behavioral effects of amphetamine enantiomers, p-methoxyamphetamine and n-alkyl-p-methoxyamphetamine ... 
      Bustamante, Diego; Díaz Véliz, Gabriela; Paeile Jacquier, Carlos; Zapata-Torres, Gerald; Cassels Niven, Bruce (PERGAMON-ELSEVIER SCIENCE LTD, 2004-10)
      The analgesic effects of (+)- and (-)-amphetamine (AMPH), (+/-)-p-methoxyamphetamine (MA), (+/-)-N-methyl-p-methoxyamphetamine (MMA) and (+/-)-N-ethyl-p-methoxyamphetamine (EMA) were compared using two different algesimetric ...
    • Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically ... 
      Román Albasini, Luciano; Díaz Véliz, Gabriela; Olave, Felipe Antonio; Aguayo, Felipe Ignacio; García Rojo, Gonzalo; Corrales, Wladimir Antonio; Silva, Juan Pablo; Ávalos, Ana María; Rojas, Paulina S.; Aliaga, Esteban; Fiedler, Jenny Lucy (Elsevier, 2020)
      Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated protein ...
    • On the role of DT- diaphorase inhibition in aminochrome- induced neurotoxicity in vivo 
      Herrera Soto, Andrea; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Muñoz, Patricia; Henny, Pablo; Steinbusch, Harry W. M.; Segura Aguilar, Juan (Springer, 2017)
      Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. ...