Browsing by Author "c2325d69-0ce5-4526-8026-5331843e5047"

Now showing items 1-3 of 3

    • Ca2+/ Calmodulin dependent protein kinase II and androgen signaling pathways modulate MEF2 activity in ... 
      Durán, Javier; Lagos, Daniel; Pavez, Mario; Troncoso, Mayarling F.; Ramos, Sebastián; Barrientos Briones, Genaro; Ibarra, Cristián; Lavandero González, Sergio; Estrada Hormazábal, Manuel (Frontiers media SA, 2017)
      Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...
    • GDF11 Modulates Ca2+-Dependent Smad2/3 signaling to prevent cardiomyocyte hypertrophy 
      Durán, Javier; Troncoso, Mayarling Francisca; Lagos, Daniel; Ramos, Sebastian; Marin, Gabriel; Estrada, Manuel (MDPI, 2018-05)
      Growth differentiation factor 11 (GDF11), a member of the transforming growth factor- family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, ...
    • GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy 
      Durán, Javier; Oyarce Díaz, César; Pavez Giani, Mario; Valladares, Denisse; Basualto Alarcón, Carla; Lagos, Daniel; Barrientos Briones, Genaro; Troncoso Magñin, Mayarling; Ibarra, Cristián; Estrada Hormazábal, Manuel; Basualto Alarcón, Carla (Public Library Science, 2016-12-15)
      Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...