Browsing by Author "c44f914f-4cc4-45ce-a20e-22f64d83091b"
Now showing items 1-12 of 12
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Rosselot, Gastón; Martínez, Jorge; Rodríguez, J. Pablo (1996)
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Fernández Gálvez, Mireya; Martínez Winkler, Jorge; Minguell Uribe, José (1990)The leukemic cell line, WEHI-3B presents a latent collagenase-like activity which is activated after trypsin treatment. The enzymatic activity is not released from cells and is specific for the degradation of interstitial ...
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Martínez, Jorge; Santibañez, Juan F. (1993)Blockade of the calcium channel inhibited, in a dose‐dependent manner, the proliferation of the IL‐3 dependent FDCP‐1 cell line and normal murine bone marrow cells. Similar results were obtained by lowering the amount of ...
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Hepp K., Juan; Zapata, Rodrigo; Buckel, Erwin; Martínez, Jorge; Uribe, Mario; Díaz, Juan Carlos; Ferrario, Mario; Sanhueza, Edgar; Pérez, Rosa María; Hunter, Bessie; Ríos, Gloria; Humeres, Roberto; Poniachik Teller, Jaime; Oksenberg Reisberg, Dan; Arrese, Marco (2008)Liver transplantation is an excellent therapeutic option for terminal liver disease. During the last decades the results of liver transplantation have improved significantly with a patient survival rate of nearly 90% at ...
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Kallens, Violeta; Tobar Bachler, Nicolás; Molina, Jessica; Bidegain, Arantzazú; Smith, Patricio C.; Porras Espinoza, Omar; Martínez, Jorge (Wiley, 2017)Chronic inflammation and metabolic reprogramming have been proposed as hallmarks of cancer development. Currently, many of the functional clues between these two phenomena are studied under the integrative view of functional ...
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Hernández, Helen; Parra, Alejandra; Tobar, Nicolas; Molina, Jessica; Kallens, Violeta; Hidalgo, Miltha; Varela, Diego; Martínez, Jorge; Porras Espinoza, Omar (Elsevier B.V., 2018)© 2018 The Authors Aerobic metabolism brings inexorably the production of reactive oxygen species (ROS), which are counterbalanced by intrinsic antioxidant defenses avoiding deleterious intracellular effects. Redox balance ...
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Tobar Bachler, Nicolás; Porras Espinoza, Omar; Smith, Patricio C.; Barros, L. Felipe; Martínez, Jorge (Wiley, 2017)Hyperglycemia is a risk factor for a variety of human cancers. Increased access to glucose and that tumor metabolize glucose by a glycolyticprocess even in the presence of oxygen (Warburg effect), provide a framework to ...
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Martínez, Jorge; Rosselot, Gastón; Rodríguez, J. Pablo (1996)
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Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar, Paula; Dotor, Javier; Smith, Patricio C.; Martínez, Jorge (2010)In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic ...
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Martínez, Jorge; Santibáñez, Juan Francisco; Vial, Clarisa; Maccioni Baraona, Ricardo (Kluwer Academic Publishers, 1992)The antineoplasic drug estramustine is an adduct of estradiol and nor-nitrogen mustard. It has been shown that this drug interferes with microtubule assembly, an effect mediated by estramustine interaction with ...
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Depix, María S.; Martínez, Jorge; Santibañez, Francisco; Rovirosa, Juana; San Martín Barrientos, Aurelio; Maccioni Baraona, Ricardo (1998)We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...
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The secretion of urokinase‐like plasminogen activator is inhibited by microtubule‐interacting drugs Santibañez, Juan F.; Maccioni Baraona, Ricardo; Martínez, Jorge (1995)The secretion of proteinases into the extracellular matrix is one of the main features of tumour cells, as related to their invasive behaviour. Considering the role of the microtubule cytoskeleton, and particularly the ...