Browsing by Author "c5405993-8b96-40a4-aa50-93a5c596e602"
Now showing items 1-20 of 20
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Romero, Asunción; Miranda, Hugo F.; Puig, Margarita M. (2010)The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentanyl and morphine, when two of them were systemically combined in a 1:1 potency ratio, in the hot plate, the acetic acid ...
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Miranda, Hugo F.; Noriega, Viviana; Olavarria, Loreto; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C. (2011)Statins, belonging to a well-known drug class used for lowering cholesterol through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also have other pleiotropic properties, such as ...
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Miranda, Hugo F.; Sierralta, Fernando; Aranda, Nicolas; Poblete, Paula; Castillo, Rodrigo; Noriega, Viviana; Prieto, Juan (Elsevier, 2018-06)Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
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Miranda, Hugo F.; Romero, Maria Asunción; Puig, Margarita M. (2012)Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction ...
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Romero, Asunción; Miranda, Hugo F.; Puig, Margarita M. (Elsevier Inc., 2010)The development of morphine-tolerance after chronic administration, reduces analgesic efficacy and is a significant clinical problem in some patients; may be managed clinically by increasing the doses of morphine and/or ...
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Miranda, Hugo F.; Noriega, Viviana; Prieto, Juan Carlos; Zanetta, Pilar; Castillo, Rodrigo; Aranda, Nicol as; Sierralta, Fernando (Nordic Association for the Publication of BCPT, 2016)Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and ...
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Miranda, Hugo F.; Puig, Margarita M.; Dursteler, Christian; Prieto, Juan Carlos; Pinardi, Gianni (2007)The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic ...
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Zepeda, Ramiro J.; Castillo, Rodrigo L.; Rodrigo Salinas, Ramón; Prieto, Juan C.; Aramburu, Ivonne; Brugere, Solange; Galdames, Katia; Noriega, Viviana; Miranda, Hugo F. (2012)Oxidative stress and endothelial dysfunction have been associated with essential hypertension (EH) mechanisms. The purpose of this study was to evaluate the effect of carvedilol and nebivolol on the oxidative stress-related ...
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Pinardi, Gianni; Pelissier Serrano, Teresa; Miranda, Hugo F. (Blackwell Publishing Ltd, 1998)Tramadol is a widely-used analgesic for pre- and post-operative pain which has a different pharmacological profile to that of classical opioids, since it does not induce respiratory depression, constipation, sedation, ...
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Miranda, Hugo F.; Noriega, Viviana; Zanetta, Pilar; Prieto, Juan Carlos (Quintessence Publishing Co. Inc., 2013)© Quintessence. Aims: To evaluate the nature of the antinociceptive interaction of systemic administration of a combination of the anticonvulsant gabapentin with the antidepressant nortriptyline, by isobolographic analysis ...
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Miranda, Hugo F.; Pinardi, Gianni (Polish Academy of Sciences, 2009)To enhance analgesia, the combinatorial use of analgesic drugs with proven efficacies is a widely-used strategy to reduce adverse side effects. The present study characterizes the antinociceptive interaction of intrathecal ...
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Miranda, Hugo F.; Pinardi, Hugo F. (2009)To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction ...
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Prieto, Juan C.; Pinardi, Gianni; Zamorano, Jaime; Larraín, Ernesto; Bermúdez, Cristián; Castillo, Rodrigo L.; Cisternas, Verónica; Miranda, Hugo F. (2007)Background: Endothelial dysfunction is associated to a lower production of nitric oxide and a reduction of endothelium mediated vasodilation. Aim: To study the effects of pharmacological agents that modify nitric oxide ...
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Miranda, Hugo F.; Sierralta, Fernando; Pinardi, Gianni (2002)1. The common mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) is the inhibition of the enzyme cyclo-oxygenase (COX), however, this inhibition is not enough to completely account for the efficacy of ...
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Pharmacological interaction between NSAIDS with clomipramine and risperidone in mice visceral pain Vargas, Claudio Gonzalez; Miranda, Hugo F.; Sierralta, Fernando; Noriega, Viviana; Prieto, Juan Carlos (Wiley-Liss Inc., 2019)Nonsteroidal anti-inflammatory drugs (NSAIDs) possess as primary action mechanism the inhibition of cyclooxygenases (COX-1, COX-2, and COX-3), thus producing a decreasing prostaglandin synthesis. This study was designed ...
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Miranda, Hugo F.; Noriega, Viviana; Prieto, Juan Carlos (2012)In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants ...
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Gonzalez, Claudia; Zegpi, Carlos; Noriega, Viviana; Prieto, Juan C.; Miranda, Hugo F. (Elsevier B.V., 2011)Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs for the management of acute and chronic pain. The role of the opioid system in the synergism between NSAIDs is not well characterized. ...
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Miranda, Hugo F.; Noriega, Viviana; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C. (2012)Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism ...
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Miranda, Hugo F.; Sierralta, Fernando; Aranda, Nicolas; Astaburuaga Poblete, Paula; Noriega, Viviana; Prieto, Juan C. (Blackwell Publishing Ltd, 2018)© 2018 Société Française de Pharmacologie et de Thérapeutique Neuropathic pain is associated with several conditions such as surgery, cancer, and diabetes and can be induced experimentally. Among the drugs used as monotherapy ...
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Miranda, Hugo F.; Noriega, Viviana; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C. (Elsevier B.V., 2013)Background: The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. Methods: This study, performed in mice using ...