Browsing by Author "c5f350f9-6443-4eac-af2c-6ede9ea19bb5"

Now showing items 1-4 of 4

    • Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by ... 
      Davidson, Sean M.; Riquelme, Jaime A.; Takov, Kaloyan; Vicencio, José M.; Boi-Doku, Claire; Khoo, Vanessa; Doreth, Christian; Radenkovic, Dina; Lavandero González, Sergio; Yellon, Derek M. (Blackwell, 2018)
      Many patients with ischaemic heart disease also have diabetes. As myocardial infarction is a major cause of mortality and morbidity in these patients, treatments that increase cell survival in response to ischaemia and ...
    • Increased production of functional small extracellular vesicles in senescent endothelial cells 
      Riquelme, Jaime; Takov, Kaloyan; Santiago Fernández, Concepción; Rossello, Xavier; Lavandero González, Sergio; Yellon, Derek M.; Davidson, Sean M. (Wiley, 2020)
      Small extracellular vesicles (EVs) are novel players in vascular biology. However, a thorough understanding of their production and function remains elusive. Endothelial senescence is a key feature of vascular ageing and ...
    • Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase ... 
      Rossello, Xavier; Riquelme, Jaime A.; Davidson, Sean M.; Yellon, Derek M. (Wiley, 2018)
      The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
    • The role of PI3K alpha isoform in cardioprotection 
      Rossello, Xavier; Riquelme, Jaime A.; He, Zhenhe; Taferner, Stasa; Vanhaesebroeck, Bart; Davidson, Sean M.; Yellon, Derek M. (Springer, 2017)
      Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, ...