Browsing by Author "c66e3df8-05d0-4cc3-9ebb-416f77677d4c"

Now showing items 1-8 of 8

    • A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization 
      Américo-Da-Silva, Luan; Diaz, Jheimmy; Bustamante, Mario; Mancilla, Georthan; Oyarzún, Ingrid; Verdejo, Hugo E.; Quiroga, Clara (FASEB, 2018)
      © FASEB. Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption by osteoclasts. The secretion capacity of mature osteoblasts requires strict control of proteostasis. Endoplasmic ...
    • Analysis of 5382insC (BRCA1) and 6174de1T (BRCA2) mutations in 382 healthy Chilean women with a family ... 
      Jara, Lilian; Ampuero Llanos, Sandra; Seccia, Lorena; Bustamante, Mario; Blanco, Rafael; Ojeda, José Manuel (2002)
      Breast cancer is the most common malignancy among women. Chilean studies reveal that this cancer presents the third highest mortality rate. A family history of breast cancer is one of the major risk factors for the development ...
    • ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle 
      Buvinic, Sonja; Almarza, Gonzalo; Bustamante, Mario; Casas, Mariana; López, Javiera; Riquelme, Manuel; Sáez, Juan Carlos; Huidobro Toro, Juan Pablo; Jaimovich Pérez, Enrique (2009)
      ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y (metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast calcium signal associated with contraction ...
    • Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2+ signals ... 
      Bustamante, Mario; Fernández Verdejo, Rodrigo; Jaimovich Pérez, Enrique; Buvinic, Sonja (American Physiological Society, 2014)
      Interleukin-6 (IL-6) is an important myokine that is highly expressed in skeletal muscle cells upon exercise. We assessed IL-6 expression in response to electrical stimulation (ES) or extracellular ATP as a known mediator ...
    • Frequency of the 185delAG mutation in the BRCA1 gene in Chilean healthy women with family history of breast ... 
      Jara, Lilian; Ampuero Llanos, Sandra; Seccia, Lorena; Bustamante, Mario; Blanco, Rafael; Santibáñez, Eudocia; Reyes, José Miguel; Ojeda, José Manuel (2002)
      BACKGROUND: Breast cancer is the most common malignancy among women, and is the second cause of cancer mortality among Chilean women. Female mortality due to breast cancer in Chile has shown a steady increase from 9.5 ...
    • Molecular analysis of the eighteen most frequent mutations in the BRCA 1 gene in 63 Chilean breast cancer families 
      Jara, Lilian; Ampuero Llanos, Sandra; Santibáñez, Eudocia; Seccia, Lorena; Rodríguez, Juan; Bustamante, Mario; Lay-Son, Guillermo; Ojeda, José Manuel; Reyes, José Miguel; Blanco, Rafael (Society of Biology of Chile, 2004)
      BRCA1 gene mutations account for nearly all families with multiple cases of both early onset breast and/or ovarian cancer and about 30% of hereditary breast cancer. Although to date more than 1,237 distinct mutations, ...
    • Novel therapies targeting cardioprotection and regeneration 
      Garrido, Valeria; Mendoza Torres, Evelyn; Riquelme, Jaime A.; Díaz, Ariel; Pizarro, Marcela; Bustamante, Mario; Chávez, Myra N.; Ocaranza, María Paz; Mellado, Rosemarie; Corbalán, Ramón; Allende Connelly, Miguel; Lavandero González, Sergio (Bentham Science Publishers, 2017)
      Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions ...
    • Therapeutic targeting of autophagy in myocardial infarction and heart failure 
      Riquelme, Jaime A.; Chávez, Myra N.; Mondaca Ruff, David; Bustamante, Mario; Vicencio, José M.; Quest, Andrew F. G.; Lavandero González, Sergio (Taylor & Francis, 2016)
      Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...