Browsing by Author "c7e60188-8191-49ba-838b-84d1b93c3f37"
Now showing items 1-20 of 22
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Lagos, Néstor; Valdés, Fernando; Orrego, Fernando (1983)The possible existence of endogenous substances other than γ-aminobutyric acid (GABA), that can also bind to rat brain GABA receptors, has been investigated in synaptic membranes derived from whole rat brain, or from ...
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Compagnon, Deida; Lembeye, Georgina; Marcos, Narvis; Ruiz-Tagle, Nathaly; Lagos, Néstor (1998)In the early fall of 1996, a bloom of the toxic dinoflagellate Alexandrium catenella occurred in a fjord in the southern part of Chile that resulted in very high levels of paralytic shellfish poisoning (PSP) toxicity (up ...
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Rivas, Mariella; García Carrasco, Carlos; Liberona Leppe, José; Lagos Wilson, Néstor (2000)Protein phosphatases are involved in many cellular processes. One of the most abundant and best studied members of this class is protein phosphatase type-2A (PP2A). In this study, PP2A was purified from the mussel Mytilus ...
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Michea Acevedo, Luis; Andrinolo, Dario; Ceppi, Hernán; Lagos, Néstor (1995)In this study, we tested the adhesion-promoting role of major intrinsic protein from both normal human (cadaver) and senile cataractous lenses. Junctional membrane solubilized proteins and pure major intrinsic protein ...
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Valenzuela, Carolina; Torres, Cristian; Muñoz, Vanina; Simbaina, Juan Carlos; Sánchez, Andrella; Bustamante, Tamara; Sepúlveda, Joaquín M.; Piron, Robin; Del Campo, Miguel; Lagos, Néstor (Elsevier Ltd, 2019)Objetive: To evaluate Neosaxitoxin (NeoSTX) as a local anesthetic drug, for pain control during and after piglet castration. Study design: Prospective, randomized and double-blind study. Animals: 24 commercial hybrids, ...
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García, Carlos; González, Viviana; Cornejo, Carlos; Palma-Fleming, Hernán; Lagos, Néstor (2004)Diarrhetic shellfish poisoning (DSP) is a gastrointestinal disease caused by fat-soluble polyether toxins produced by dinoflagellates and accumulated in shellfish. Up to the present, only four fat-soluble polyethers have ...
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García, Carlos; Pruzzo, Matías; Rodríguez-Unda, Nelson; Contreras, Cristóbal; Lagos, Néstor (Japanese Society of Toxicology, 2010)This paper shows the detection of Diarrhetic Shellfish Poison (DSP) phycotoxins, using HPLC-FLD with pre-column derivatization procedure and HPLC-MS methods, in the analysis of shell-fish extracts tested positive with the ...
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Hinzpeter Cohen, Jaime Rodrigo; Barrientos Mendoza, Cristian Nelson; Zamorano Cadenas, Álvaro Igor; Martínez, Álvaro; Palet Bonell, Miguel Jaime Luis; Wulf Ibáñez, Rodrigo Alfonso; Barahona Vásquez, Maximiliano Andrés; Sepúlveda, Joaquín M.; Guerra, Matías; Bustamante, Tamara; Del Campo, Miguel; Tapia, Eric; Lagos, Néstor (Pergamon-Elsevier Science Ltd., 2016)Improvements in pain management techniques in the last decade have had a major impact on the practice of total knee arthroplasty (TKA). Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block ...
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García, Carlos; Schonstedt, Valeria; Santelices, Juan Palbo; Lagos, Néstor (2006)This study describes the detection of high amount of 7-O-acyl-derivative dinophysistoxin-1 (Dinophysistoxin-3) in filter bivalves collected on February 2005 in the Seno de Reloncaví, Puerto Montt City, Southern Chile, in ...
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García, Carlos; Lagos, Marcelo; Truan, Dominique; Lattes, Karinna; Véjar, Omar; Chamorro, Beatriz; Iglesias, Verónica; Andrinolo, Darío; Lagos, Néstor (Society of Biology of Chile, 2005)This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 +/- 61.37 microg/100 ...
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Garcia, Carlos; Rodriguez-Unda, Nelson; Contreras, Cristóbal; Barriga, Andrés; Lagos, Néstor (2012)Lipophilic toxins associated with diarrhoeic toxins were found in Mytilus chilensis (Blue mussels) and Aulacomya ater (Ribbed mussels). These shellfish samples were collected from Chiloe Island, Southern Chile. The samples ...
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García, Carlos; Truan, Dominique; Lagos, Marcelo; Santelices, Juan Pablo; Díaz, Juan Carlos; Lagos, Néstor (2005)This paper describes for the first time a massive intoxication episode due to consumption of shellfish contaminated with 7-O-acyl-derivative dinophysistoxin-1, named Dinophysistoxin-3 (DTX-3). 7-O-acyl-derivative ...
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Lagos, Néstor (1998)Ecological and health problems posed by microalgal blooms (red tides) occurring in the Southern part of Chile are reviewed. Out of the six human illnesses provoked by microalgal toxins, paralytic shellfish poisoning is the ...
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Riquelme, Gricel; Sepúlveda, Joaquín M.; Ghumgham, Zaki Al; Campo, Miguel del; Montero, Cecilia; Lagos, Néstor (Pergamon-Elsevier Science LTD, 2018)Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage gated sodium channels at the axonal level, impeding nerve impulse ...
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Del Campo, Miguel; Toledo, Héctor; Lagos, Néstor (2013)The aim of this study was to analyze the effect of Okadaic Acid (OA) on the proliferation of gastric and colon epithelial cells, the main target tissues of the toxin. We hypothesized that OA, at sublethal doses, activates ...
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García, Carlos; Bravo, María Del Carmen; Lagos, Marcelo; Lagos, Néstor (2004)In July 5, 2002 fishermen working in harvesting sea urchin (Loxechinus albus) in the Patagonia Chilean fjords were intoxicated by consumption of filter-feeder bivalve Aulacomya ater. After the ingestion of 7-9 ribbed mussel, ...
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Mardones, Pamela; Andrinolo, Darío; Csendes Juhasz, Attila; Lagos, Néstor (2004)The aim of this work was to study the mechanisms involved in intestinal permeability of gonyautoxins. For this purpose, the influence on transmucosal resistance of gonyautoxins and their permeability was investigated in ...
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García, Carlos; Pereira, Paulo; Valle, Luis; Lagos, Néstor (Society of Biology of Chile, 2003)Diarrhetic shellfish poisoning (DSP) is a gastrointestinal disease caused by lipid soluble polyether toxins produced by dinoflagellates and accumulated in shellfish. Diarrhetic shellfish poisoning is a worldwide threat to ...
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del Campo, Miguel; Zhong, Ta- Ying; Tampe, Ricardo; García Nannig, Lorena; Lagos, Néstor (Elsevier Ltd, 2017)© 2016 Elsevier LtdOne of the proposed mechanisms to explain why Diarrhetic Shellfish Poison (DSP) toxins are tumor promoters is founded on the capacity of these toxins to increase TNF-α secretion. Although macrophages are ...
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The gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healty adults Garrido, Rogelio; Lagos, Néstor; Lattes, Karinna; García, Carlos; Azolas, Rodrigo; Bocic, Gunther; Cuneo, Aldo; Chiong, Hector; Jensen, Cristian; Henríquez, Ana; Fernández, Cristian (2004)The primary clinical symptom of Paralytic Shellfish Poisoning is acute paralytic illness produced by paralyzing toxins. Paralytic shellfish poison is formed by a mixture of phycotoxins and their toxicity is due to its ...