Browsing by Author "c808c05f-8b63-4362-bd2c-5aa833402d5a"

Now showing items 1-4 of 4

    • Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized ... 
      Mathur, Chhavi; Johnson, Kory R.; Tong, Brian A.; Miranda, Pablo; Srikumar, Deepa; Basilio, Daniel; Latorre, Ramón; Bezanilla, Francisco; Holmgren, Miguel (Nature Publishing Group, 2018)
      © 2018 The Author(s). Local translation of membrane proteins in neuronal subcellular domains like soma, dendrites and axon termini is well-documented. In this study, we isolated the electrical signaling unit of an axon by ...
    • Energy landscape of the reactions governing the Na + deeply occluded state of the Na +/K +-ATPase in the ... 
      Castillo, Juan P.; De Giorgis, Daniela; Basilio, Daniel; Gadsby, David C.; Rosenthal, Joshua J.C.; Latorre, Ramón; Holmgren, Miguel; Bezanill, Francisco (2011)
      The Na +/K + pump is a nearly ubiquitous membrane protein in animal cells that uses the free energy of ATP hydrolysis to alternatively export 3Na + from the cell and import 2K + per cycle. This exchange of ions produces a ...
    • Mechanism of potassium ion uptake by the Na 
      Castillo, Juan P.; Rui, Huan; Basilio, Daniel; Das, Avisek; Roux, Benoît; Latorre, Ramón; Bezanilla, Francisco; Holmgren, Miguel (Nature Publishing Group, 2015)
      © 2015 Macmillan Publishers Limited. All rights reserved. The Na<sup>+</sup>/K<sup>+</sup>-ATPase restores sodium (Na<sup>+</sup>) and potassium (K<sup>+</sup>) electrochemical ...
    • Probing the conformation of a conserved glutamic acid within the Cl- pathway of a CLC H+/Cl- exchanger 
      Vien, Malvin; Basilio, Daniel; Leisle, Lilia; Accardi, Alessio (Rockefeller University Press, 2017)
      The CLC proteins form a broad family of anion-selective transport proteins that includes both channels and exchangers. Despite extensive structural, functional, and computational studies, the transport mechanism of the CLC ...