Browsing by Author "c8ac7ef8-41df-4c59-bc8e-a67be0a2735c"

Now showing items 1-11 of 11

    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ ... 
      Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein ... 
      Cárdenas, César; Müller, Marioly; Jaimovich Pérez, Enrique; Pérez, Francisco; Buchuk, Diego; Quest, Andrew F. G.; Carrasco, Maria Angélica (2004)
      Membrane depolarization of skeletal muscle cells induces slow inositol trisphosphate-mediated calcium signals that regulate the activity of transcription factors such as the cAMP-response element-binding protein (CREB), ...
    • Editorial: inter-organelle calcium communication in cancer 
      Cárdenas, César; Pinton, Paolo; Bultynck, Geert (Frontiers Media SA, 2018)
    • Erratum to: Targeting hepatic glutaminase activity to ameliorate hyperglycemia (Nature Medicine, (2018), ... 
      Miller, Russell A.; Shi, Yuji; Lu, Wenyun; Pirman, David A.; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas, César; Wan, Min; Foskett, J. Kevin; Park, Junyoung O.; Zhang, Yiyi; Holland, William L.; Rabinowitz, Joshua D.; Birnbaum, Morris J. (Nature Publishing Group, 2018)
      © 2018, The Publisher. In the version of this article initially published, the “[13C2]α-ketoglutarate” label on Fig. 1g is incorrect. It should be “[13C5]α-ketoglutarate”. Additionally, in Fig. 3b, the “AAV-GFP” group is ...
    • InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer 
      Lovy, Alenka; Foskett, J. Kevin; Cárdenas, César (Taylor & Francis, 2016-06)
      Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca2+ transfer to mitochondria as an unexpected requirement for ...
    • Mitochondria and calcium regulation as basis of neurodegeneration associated with aging 
      Müller, Marioly; Ahumada-Castro, Ulises; Sanhueza, Mario; González Billault, Christian; Court, Felipe A.; Cárdenas, César (Frontiers Media S.A., 2018)
      © 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
    • Mitochondrial Ca2+ signals in autophagy 
      Cárdenas, César; Foskett, J. Kevin (Elsevier Ltd, 2012)
      Macroautophagy (autophagy) is a lysosomal degradation pathway that is conserved from yeast to humans that plays an important role in recycling cellular constituents in all cells. A number of protein complexes and signaling ...
    • MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: ... 
      Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka; Pardo, Evelyn; Molgό, Jordi; Cárdenas, César (Taylor and Francis Inc., 2019)
      © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent ...
    • Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and ... 
      Cataldo, Luis Rodrigo; Mizgier, María Luisa; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos Vidal, Paola; Busso, Dolores; Olmos, Pablo; Galgani Fuentes, José; Santos, José Luis; Cortés, Víctor A. (Public Library of Science, 2017)
      © 2017 Cataldo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
    • Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria 
      Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaňa, Fabian; Bustos, Galdo; Urra, Felix; Smith, Natalia; Molgó, Jordi; Diehl, J. Alan; Ridky, Todd W.; Foskett, J. Kevin (Elsevier B.V., 2016)
      © 2016 The Authors.In the absence of low-level ER-to-mitochondrial Ca2+ transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we ...
    • The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast ... 
      Schmeda-Hirschmann, Guillermo; Gomez, Celeste Vega; Rojas de Arias, Antonieta; Burgos-Edwards, Alberto; Alfonso, Jorge; Rolon, Miriam; Brusquetti, Francisco; Netto, Flavia; Urra, Félix A.; Cárdenas, César (Elsevier Ireland Ltd, 2017)
      © 2017 Elsevier Ireland Ltd Ethnopharmacological relevance Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections. Aim of the study The objective of the study was ...