Now showing items 1-11 of 11

    • Utreras Puratich, Elías; Henríquez, Daniel R.; Contreras Vallejos, Erick; Olmos, Cristina; Di Genova, Alex; Maass Sepúlveda, Alejandro; Kulkarni, Ashok B.; González Billault, Christian (2013)
      Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
    • Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2017)
      The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size ...
    • Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, Maria José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams and Wilkins, 2017)
      © 2017 International Association for the Study of Pain. The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent ...
    • Maldonado, Horacio; Ramírez, Eugenio; Utreras Puratich, Elías; Pando, María E.; Kettlun, Ana M.; Chiong Lay, Mario; Kulkarni, Ashok B.; Collados, Lucía; Puente, Javier; Cartier Rovirosa, Luis; Valenzuela, María A. (2011)
      Human T-cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease characterized by selective loss of axons and myelin in the corticospinal tracts. This ...
    • Rudrabhatla, Parvathi; Utreras Puratich, Elías; Jaffe, Howard; Kulkarni, Ashok B. (Public Library of Science, 2014)
      Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration. In brain, Cdk5 activity is specific to post-mitotic ...
    • Quintanilla, Rodrigo A.; Utreras Puratich, Elías; Cabezas Opazo, Fabián A. (Hindawi Publishing Corporation, 2014)
      © 2014 Rodrigo A. Quintanilla et al.Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases. Recent evidence has showed ...
    • Utreras Puratich, Elías; Hamada, Ryusuke; Prochazkova, Michaela; Terse, Anita; Takahashi, Satoru; Ohshima, Toshio; Kulkarni, Ashok B. (BioMed Central Ltd., 2014)
      Background: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific ...
    • Rozas, Pablo; Lazcano, Pablo; Piña, Ricardo; Cho, A.; Terse, Anita; Pertusa, María; Madrid, Rodolfo; González Billault, Christian; Kulkarni, Ashok B.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2016)
      We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
    • Utreras Puratich, Elías; Prochazkova, Michaela; Terse, Anita; Gross, Jacklyn; Keller, Jason; Iadarola, Michael J.; Kulkarni, Ashok B. (2013)
      Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...
    • Sandoval, Rodrigo; Lazcano, Pablo; Ferrari, Franco; Pinto Pardo, Nicolas; González Billault, Christian; Utreras Puratich, Elías (Frontiers Media SA, 2018)
      The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...
    • Moya, Pablo; Delgado, Claudia; Cisternas, Marisol; Henriquez, Francisca; Gómez, Isabel; Utreras Puratich, Elías; Wendland, Jens; Kulkarni, Ashok; Murphy, Dennis (Elsevier, 2017)