Now showing items 1-6 of 6

    • Córdova Jara, Luis; Loi, Florence; Lin, Tzu-Hua; Gibon, Emmanuel; Pajarinen, Jukka; Nabeshima, Akira; Lu, Laura; Yao, Zhenyu; Goodman, Stuart B. (Wiley, 2017)
      The modulation of macrophage phenotype from pro-inflammatory (M1) to tissue healing (M2) via exogenous addition of interleukin-4 (IL-4) facilitates osteogenesis; however, the molecular mediators underlying this phenomenon ...
    • Loi, Florence; Córdova Jara, Luis; Pajarinen, Jukka; Lin, Tzu-hua; Yao, Zhenyu; Goodman, Stuart B. (Elsevier, 2016)
      The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis, metabolic bone disease, tumors, ...
    • Nabeshima, Akira; Pajarinen, Jukka; hua Lin, Tzu; Jiang, Xinyi; Gibon, Emmanuel; Córdova, Luis; Loi, Florence; Lu, Laura; Jämsen, Eemeli; Egashira, Kensuke; Yang, Fan; Yao, Zhenyu; Goodman, Stuart (Elsevier Ltd, 2017)
      Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
    • Lin, Tzu-hua; Pajarinen, Jukka; Sato, Taishi; Loi, Florence; Fan, Changchun; Córdova Jara, Luis; Nabeshima, Akira; Gibon, Emmanuel; Zhang, Ruth; Yao, Zhenyu; Goodman, Stuart (Elsevier, 2016)
      Total joint replacement is a cost-effective surgical procedure for patients with end-stage arthritis. Wear particle-induced chronic inflammation is associated with the development of periprosthetic osteolysis. Modulation ...
    • Lin, Tzuhua; Pajarinen, Jukka; Nabeshima, Akira; Córdova, Luis; Loi, Florence; Gibon, Emmanuel; Lu, Laura; Nathan, Karthik; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling ...
    • Lu, Laura; Loi, Florence; Nathan, Karthik; Lin, Tzu; Pajarinen, Jukka; Gibon, Emmanuel; Nabeshima, Akira; Cordova, Luis; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Bone fractures are among the most common orthopaedic problems that affect individuals of all ages. Immediately after injury, activated macrophages dynamically contribute to and regulate an acute inflammatory response that ...