Browsing by Author "cbac23d5-7006-48f2-8b94-82349f065903"

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    • A simple synthesis of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B 
      Castro Castillo, Vicente; Suárez Rozas, Cristian; Simpson, Sebastián; Barriga González, Andrés (Springer, 2017)
      We followed a simple, inexpensive, and efficient route to synthesize a series of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B, with the expectation that this scaffold might exhibit ...
    • Telomerase inhibition by a new synthetic derivative of the aporphine alkaloid boldine 
      Noureini, Sakineh Kazemi; Kheirabadi, Mitra; Masoumi, Fatima; Khosrogerdi, Farve; Zarei, Younes; Suárez Rozas, Cristian; Salas Norambuena, Julio; Cassels Niven, Bruce (MDPI, 2018-04)
      Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. ...