Now showing items 1-12 of 12

    • González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ...
    • Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana M.; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sanchez, Cesar; Pizarro, Marcela; Corvalan, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martinez, Gonzalo (Sociedad Médica de Santiago, 2018-01)
      Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, ...
    • Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana María; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martínez, Gonzalo (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, ...
    • Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Greig, Douglas; Mellado, Rosemarie; Concepción, Roberto; Sepulveda, Luis; Vukasovic, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraon (2010)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez, Fernando; Fernández, Rodrigo; Saavedra, Rodrigo; Sitges, Marta; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Springer Verlag, 2018)
      © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Left atrial (LA) contraction is essential for left ventricular (LV) filling during exertion. We sought to evaluate the relationship of LA contraction ...
    • Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rosemarie; García Nannig, Lorena; Salas, Daniela; Vivar, Raúl; Vukasovic, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (2008)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Sanz-de la Garza, Maria; Giraldeau, Geneviève; Marin, Josefa; Grazioli, Gonzalo; Esteve, Montserrat; Gabrielli, Luigi; Brambila, Carlos; Sanchis, Laura; Bijnens, Bart; Sitges, Marta (Springer Verlag, 2017)
      © 2017, Springer-Verlag Berlin Heidelberg. Background: Characteristic right ventricle (RV) remodelling is related to endurance exercise in male athletes (MAs), but data in female athletes (FAs) are scarce. Our aim was to ...
    • Winter, José Luis; Castro, Pablo; Meneses, Luis; Chalhub, Mónica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong Lay, Mario; Concepción, Roberto; Mellado, Rosemarie; Hernández, Claudia; Uribe, Sergio; Lavandero González, Sergio (2010)
      Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by ...
    • Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma, Alejandra; Sagredo, Andrea Ramirez; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero González, Sergio (Academic Press, 2018)
      © 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
    • Ocaranza, María Paz; Valderas, Patricio; Moya, Jackeline; Gabrielli, Luigi; Godoy, Iván; Córdava, Samuel; Mac Nab, Paul; García Nannig, Lorena; Farías, Luis; Jalil, Jorge E. (BMC, 2020)
      BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...
    • Villar Fincheira, Paulina; Sanhueza Olivares, Fernanda; Norambuena Soto, Ignacio; Cancino Arenas, Nicole; Hernández Vargas, Felipe; Troncoso Cotal, Rodrigo; Gabrielli, Luigi; Chiong Lay, Mario (Frontiers Media, 2021)
      IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate ...
    • Herrera, Sebastián; Gabrielli, Luigi A.; Paredes, Alejandro; Saavedra, Rodrigo; Paz Ocaranza, María; Fuentes Sepúlveda, Pablo Ignacio; Donoso, Hernán; López, Leonel; Verdejo, Hugo; Baraona, Fernando (Soc. Médica Santiago, 2016)
      Background: Pulmonary arterial hypertension (PAH) is a rare and progressive disease. Long-term survival remains poor despite of advances in specific vasodilator therapy. Aim: To describe the survival rate in a cohort of ...