Browsing by Author "cf2b8c10-4288-40b5-a9e9-9aaf33699ac9"

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    • Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway 
      Parra, Valentina; Verdejo, Hugo E.; Iglewski, Myriam; Del Campo, Andrea; Troncoso, Rodrigo; Jones, Deborah; Zhu, Yi; Kuzmicic Previtali, Jovan Paolo; Pennanen, Christian; López Crisosto, Camila; Jaña, Fabián; Ferreira, Jorge; Noguera, Eduard; Chiong Lay, Mario; Bernlohr, David A.; Klip, Amira (2014)
      Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function ...
    • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes 
      Kuzmicic Previtali, Jovan Paolo; Parra, Valentina; Verdejo, Hugo E.; López Crisosto, Camila; Chiong Lay, Mario; García Nannig, Lorena; Jensen, Michael D.; Bernlohr, David A.; Castro, Pablo F.; Lavandero González, Sergio (Elsevier Inc., 2014)
      © 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...