Now showing items 1-5 of 5

    • Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • Andaur, Rodrigo; Tapia, Julio C.; Moreno, José; Soto, Leopoldo; Armisen, Ricardo; Marcelain Cubillos, Katherine (Impact Journals LLC, 2018)
      © Andaur et al. Enhanced radiosensitivity at low doses of ionizing radiation (IR) (0.2 to 0.6 Gy) has been reported in several cell lines. This phenomenon, known as low doses hyperradiosensitivity (LDHRS), appears as an ...
    • Tapia, Julio C.; Niechi, Ignacio (Elsevier Ireland Ltd, 2019)
      The endothelin-1 (ET-1) axis contributes to the pathophysiology of several cancers by promoting tumor development and progression. This peptide is activated from its precursor, big ET-1, by endothelin-converting enzyme-1 ...
    • Fernández, Jaime G.; Rodríguez, Diego A.; Valenzuela, Manuel; Calderon, Claudia; Urzúa, Ulises; Munroe, David; Rosas, Carlos; Lemus, David; Díaz, Natalia; Wright, Mathew C.; Leyton Campos, Lisette; Tapia, Julio C.; Quest, Andrew F. G. (BioMed Central Ltd., 2014)
      © 2014 Fernández et al.; licensee BioMed Central Ltd.Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an ...
    • Sagredo, Alfredo I.; Sagredo, Eduardo A.; Cappelli, Claudio; Báez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (John Wiley and Sons Ltd., 2018)
      © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism ...