Browsing by Author "d0cd8e3e-ed5d-491d-9580-6698b0a3f299"

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    • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive ... 
      Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ... 
      Andaur, Rodrigo; Tapia, Julio C.; Moreno, José; Soto, Leopoldo; Armisen, Ricardo; Marcelain Cubillos, Katherine (Impact Journals LLC, 2018)
      © Andaur et al. Enhanced radiosensitivity at low doses of ionizing radiation (IR) (0.2 to 0.6 Gy) has been reported in several cell lines. This phenomenon, known as low doses hyperradiosensitivity (LDHRS), appears as an ...
    • Endothelin-converting enzyme-1 in cancer aggressiveness 
      Tapia, Julio C.; Niechi, Ignacio (Elsevier Ireland Ltd, 2019)
      The endothelin-1 (ET-1) axis contributes to the pathophysiology of several cancers by promoting tumor development and progression. This peptide is activated from its precursor, big ET-1, by endothelin-converting enzyme-1 ...
    • Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent ... 
      Fernández, Jaime G.; Rodríguez, Diego A.; Valenzuela, Manuel; Calderon, Claudia; Urzúa, Ulises; Munroe, David; Rosas, Carlos; Lemus, David; Díaz, Natalia; Wright, Mathew C.; Leyton Campos, Lisette; Tapia, Julio C.; Quest, Andrew F. G. (BioMed Central Ltd., 2014)
      © 2014 Fernández et al.; licensee BioMed Central Ltd.Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an ...