Browsing by Author "d211295d-fa33-4168-8b98-ecb7b62997de"

Now showing items 1-3 of 3

    • Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response 
      Dufey, Estefanie; Bravo San Pedro, José; Eggers Aracena, Cristián; González Quiroz, Matías; Urra Zúñiga, Hery; Sagredo Campos, Alfredo; Sepúlveda Alvarado, Denisse; Pihán Najle, Philippe; Carreras Sureda, Armando; Hazari, Younis; Sagredo, Eduardo A.; Gutiérrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Rémy; Chevet, Eric; Álvarez, Alejandra R.; Godoy, Patricio; Walter, Peter; Glavic Maurer, Álvaro; Kroemer, Guido; Hetz Flores, Claudio (Nature, 2020)
      The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1 ...
    • On the right track to treat movement disorders: promising therapeutic approaches for Parkinson’s and ... 
      Troncoso Escudero, Paulina; Sepúlveda Alvarado, Denisse; Pérez Arancibia, Rodrigo; Parra Peña, Alejandra; Arcos, Javiera; Grunenwald, Felipe; Vidal Gómez, René (Frontiers Media, 2020)
      Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are ...
    • Role of collagen chaperone HSP47 on the activation of endoplasmic reticulum stress sensor IRE1α 
      Sepúlveda Alvarado, Denisse (Universidad de Chile, 2018)
      Alteraciones en la homeostasis del retículo endoplasmático (RE) promueven la acumulación de proteínas mal plegadas en su lumen, una condición celular denominada estrés de RE. La adaptación al estrés de RE depende de la ...