Browsing by Author "d2458c3d-5144-4689-b5b6-78b372cf8013"

Now showing items 1-8 of 8

    • Alterations of rat liver mitochondrial oxidative phosphorylation and calcium uptake by benzo[a]pyrene 
      Salazar, Inés; Pavani, Mario; Aranda, Waldo; Maya Arango, Juan; Morello Casté, Antonio; Ferreira, Jorge (2004)
      We report that oxidative phosphorylation and Ca2+ uptake processes are enhanced in liver mitochondria isolated from benzo[a]pyrene (B[a]P)-treated rats. The carcinogen did not affect either the respiratory control index ...
    • Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition ... 
      Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Destabilization of mitochondrial functions as a target against breast cancer progression: Role of ... 
      Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)
      Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
    • Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)- anthracenone derivatives on tumor cell respiration 
      Araya Maturana, Ramiro; Cardona, Wilson; Cassels Niven, Bruce; Delgado Castro, Tomás; Ferrada Parker, Jorge; Miranda, Dante; Pavani, Mario; Pessoa Mahana, Hernán; Soto Delgado, Jorge; Weiss López, Boris (Elsevier Ltd., 2006-02-28)
      A series of tricyclic hydroquinones, incorporating a carbonyl group in the ortho position relative to the phenol function, were tested as inhibitors of oxygen uptake against the TA3 mouse carcinoma cell line and its ...
    • Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins ... 
      Maya Arango, Juan; Rodríguez, Andrés; Pino, Laura; Pabón, Adriana; Ferreira, Jorge; Pavani, Mario; Repetto Scaramelli, Yolanda; Morello Casté, Antonio (Society of Biology of Chile, 2004)
      Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
    • Inhibitory effect of vanillin-like compounds on respiration and growth of adenocarcinoma TA3 and its ... 
      Cordano, G.; Pezoa Olivares, Jacqueline; Muñoz, S.; Rivera, E.; Medina, Jorge; Núñez Vergara, Luis; Pavani, Mario; Guerrero A., Aníbal; Ferreira Parker, Jorge (ELSEVIER SCIENCE BV, 2002-09)
      The effects of some imine and amine derivatives of vanillin on the respiration rate of mouse mammary adenocarcinoma TA3 line, its multiresistant variant TA3-MTX-R line and mouse hepatocytes, together with their respective ...
    • Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines 
      Jara Sandoval, José Antonio; Rojas Rivera, Diego; Castro Castillo, Vicente; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Parra, Eduardo; Pavani, Mario; Maya Arango, Juan Diego; Ferreira Parker, Jorge; Catalán Díaz, Mabel (Elsevier, 2020)
      Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
    • Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of ... 
      Urra Faúndez, Félix; Córdova Delgado, Miguel; Lapier, Michel; Orellana Manzano, Andrea; Acevedo Arévalo, Luis; Pessoa Mahana, Hernán; González Vivanco, Jaime; Martínez Cifuentes, Maximiliano; Ramírez Rodríguez, Oney; Millas Vargas, Juan; Weiss López, Boris; Pavani, Mario; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Academic Press Elsevier Science, 2016)
      Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...