Browsing by Author "d2cb3296-f36f-4f7f-92b9-b2268e45131f"

Now showing items 1-18 of 18

    • 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in ... 
      Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martín Núñez, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Patricia (2010)
      Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and ...
    • Assessing the importance of domestic vaccine manufacturing centers: An overview of immunization programs, ... 
      Rey Jurado, Emma; Tapia, Felipe; Muñoz Durango, Natalia; Lay, Margarita K.; Carreño Marquez, Leandro J.; Riedel, Claudia A.; Bueno, Susan M.; Genzel, Yvonne; Kalergis, Alexis M. (Frontiers Media SA, 2018)
      Vaccines have significantly reduced the detrimental effects of numerous human infectious diseases worldwide, helped to reduce drastically child mortality rates and even achieved eradication of major pathogens, such as ...
    • Deletion of a prophage-like element causes attenuation of Salmonella enterica serovar Enteritidis and ... 
      Araya, Daniela V.; Quiroz, Tania S.; Tobar, Hugo E.; Lizana, Rodrigo J.; Quezada, Carolina P.; Santiviago, Carlos A.; Riedel, Claudia A.; Kalergis, Alexis M.; Bueno, Susan M. (2010)
      Salmonella enterica serovar Enteritidis (S. Enteritidis) is a wide host range serovar belonging to the S. enterica genus. Worldwide, it is one of the most frequent causes of food borne disease. Similar to S. Typhimurium, ...
    • Excision of an unstable pathogenicity island in salmonella enterica serovar enteritidis is induced during ... 
      Quiroz, Tania S.; Nieto, Pamela A.; Tobar, Hugo E.; Salazar-Echegarai, Francisco J.; Lizana, Rodrigo J.; Quezada, Carolina P.; Santiviago, Carlos A.; Araya, Daniela V.; Riedel, Claudia A.; Kalergis, Alexis M.; Bueno, Susan M. (2011)
      The availability of the complete genome sequence of several Salmonella enterica serovars has revealed the presence of unstable genetic elements in these bacteria, such as pathogenicity islands and prophages. This is the ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, ... 
      Baudrand, Rene; Campino, Carmen; Carvajal, Cristian A.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Sateler, Javiera; Cornejo, Javiera; San Martín Núñez, Betty; Dominguez, Jose M.; Cerda, Jaime; Mosso, Lorena M.; Owen, Gareth I.; Kalergis, Alexis M.; Fardella, Patricia (2011)
      Metabolic syndrome (MetS) may have increased cortisol (F) production caused by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis dysregulation. F is then mainly metabolized by ...
    • Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, ... 
      Marsac, Delphine; García, Stephanie; Fournet, Alexandra; Aguirre, Adam; Pino, Karla; Ferrés, Marcela; Kalergis, Alexis M.; López-Lastra, Marcelo; Veas, Francisco (2011)
      Background: Andes virus (ANDV), a rodent-borne Hantavirus, is the major etiological agent of Hantavirus cardiopulmonary syndrome (HCPS) in South America, which is mainly characterized by a vascular leakage with high rate ...
    • Interplay between behavioural thermoregulation and immune response in mealworms 
      Catalán, Tamara P.; Niemeyer, Hermann M.; Kalergis, Alexis M.; Bozinovic, Francisco (2012)
      Since the preferential body temperature should positively correlate with physiological performance, behavioural fever should enhance an organism's immune response under an immune challenge. Here we have studied the ...
    • Is there an effect of environmental temperature on the response to an antigen and the metabolic rate in ... 
      Ramírez Otarola, Natalia; Espinoza, Janyr; Kalergis, Alexis M.; Sabat Kirkwood, Alejandro Pablo (Pergamon-Elsevier Science LTD, 2018)
      Environmental temperature is a variable that influences all aspects of organisms, from physiological, e.g. immune function, and morphological traits to behavior. Recent studies have reported that environmental temperature ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for ... 
      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...
    • Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma 
      Espinoza, Jaime A.; Riquelme, Ismael; Sagredo, Eduardo A.; Rosa, Lorena; García, Patricia; Bizama, Carolina; Apud-Bell, María; Leal, Pamela; Weber, Helga; Benavente, Felipe; Vargas, Sergio; Romero, Diego; Kalergis, Alexis M.; Roa, Juan Carlos (Blackwell Publishing Ltd, 2019)
      Aims: Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels ...
    • Mucosal Vaccination with Lactococcus lactis-Secreting Surface Immunological Protein Induces Humoral and ... 
      Díaz Dinamarca, Diego A.; Hernández, Carlos; Escobar, Daniel F.; Soto, Daniel A.; Muñoz, Guillermo A.; Badilla, Jesús F.; Manzo, Ricardo A.; Carrión, Flavio; Kalergis, Alexis M.; (MDPI, 2020)
      Group BStreptococcus(GBS) is the primary etiological agent of sepsis and meningitis in newborns and is associated with premature birth and stillbirth. The development of a licensed vaccine is one of the pending challenges ...
    • Pathogen- and diet-dependent foraging, nutritional and immune ecology in mealworms 
      Catalán, Tamara P.; Barceló, Matías; Niemeyer, Hermann M.; Kalergis, Alexis M.; Bozinovic, Francisco (2011)
      Background: Feeding habits and dietary nutritional content may play a key role in pathogendependent foraging ecology, because mounting an effective immune response is costly for the host. Hypothesis: Since immune defence ...
    • Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals ... 
      Jerez, Sofía; Toledo Araya, Héctor; Thaler, Roman; Charlesworth, M. Cristine; López-Solís, Remigio; Kalergis, Alexis M.; Céspedes, Pablo F.; Dudakovic, Amel; Stein, Gary S.; van Wijnen, Andre J.; Galindo, Mario A. (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc.Osteosarcomas are the most prevalent bone tumors in pediatric patients, but can also occur later in life. Bone tumors have the potential to metastasize to lung and occasionally other vital ...
    • Response to lipopolysaccharide in Octodon degus pups produces age-related sickness behavior but does not ... 
      Ramírez Otarola, Natalia; Espinoza, Janyra; Kalergis, Alexis M.; Sabat Kirkwood, Alejandro Pablo (Wiley-Blackwell, 2019)
      During vertebrate development, the immune function is inefficient and is mainly controlled by innate defense. While there have been detailed studies of various aspects of innate immune function, the effects of this function ...
    • Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic ... 
      Salazar, Lorena; Aravena, Octavio; Contreras Levicoy, Juan; Pesce Reyes, Bárbara; Catalán Martina, Diego; Zúñiga, Roberto; Iruretagoyena, Mirentxu; Kalergis, Alexis M.; Aguillón Gutiérrez, Juan Carlos (2007)
      Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...
    • Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the ... 
      Amador, Cristián A.; Barrientos, Víctor; Peña, Juan; Herrada, Andrés A.; González, Magdalena; Valdés, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M.; Michea Acevedo, Luis (Lippincott Williams and Wilkins, 2014)
      Adaptive immune response has been implicated in inflammation and fibrosis as a result of exposure to mineralocorticoids and a high-salt diet. We hypothesized that in mineralocorticoid-salt-induced hypertension, activation ...
    • Surface Immunogenic Protein of Streptococcus Group B is an Agonist of Toll-Like Receptors 2 and 4 and a ... 
      Díaz Dinamarca, Diego A.; Manzo, Ricardo A.; Soto, Daniel A.; Avendaño Valenzuela, María José; Bastías, Diego N.; Soto, Paulina I.; Escobar, Daniel F.; Vásquez Sáez, Valeria; Carrión, Flavio; Pizarro Ortega, Magdalena S.; Wilson Moya, Christian A. M.; Berríos, Julio; Kalergis, Alexis M.; Vásquez, Abel E. (MDPI, 2020)
      Vaccine-induced protection against pathogens, especially subunit-based vaccines, are related to antigen properties but mainly in their ability to stimulate the immune system by the use of an adjuvant. Modern vaccines are ...