Browsing by Author "d40b15cb-0d4e-4caa-9421-644b6426c359"

Now showing items 1-11 of 11

    • Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor 
      Prades, Roger; Guerrero, Simón; Araya, Eyleen; Molina, Claudia; Salas, Edison; Zurita, Esther; Selva, Javier; Egea, Gustavo; López-Iglesias, Carmen; Teixidó, Meritxell; Kogan Bocian, Marcelo; Giralt, Ernest (2012)
      The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features ...
    • Determination of mefenamic acid and paracetamol by first derivative spectrophotometry 
      Toral Ponce, María; Richter Duk, Pablo; Araya, Eyleen; Fuentes, Sandra (Marcel Dekker Inc., 1996)
    • Exploring the influence of diels–alder linker length on photothermal molecule release from gold nanorods 
      Vetterlein, Claudia; Vásquez Salfate, Rodrigo; Bolaños, Karen; Acosta, Gerardo A.; Guzman, Fanny; Albericio, Fernando; Celis, Freddy; Campos, Marcelo; Kogan Bocian, Marcelo; Araya, Eyleen (Elsevier, 2018-06)
      We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels-Alder adducts of different lengths (n = 4 and n = 9). The functionalized GNRs were irradiated ...
    • Gold nanoparticle based double‑labeling of melanoma extracellular vesicles to determine the specificity of ... 
      Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Gold nanoparticles for photothermally controlled drug release 
      Guerrero, Ariel R.; Hassan, Natalia; Escobar, Carlos A.; Albericio, Fernando; Kogan Bocian, Marcelo; Araya, Eyleen (Future Medicine Ltd., 2014)
      © 2014 Future Medicine Ltd. In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is ...
    • Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates 
      Bastus, Neus G.; Kogan Bocian, Marcelo; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio; Labarta, Amilcar; Giralt, Ernest; Puntes, Victor F. (2007)
      Nanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle ...
    • Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 
      Velasco Aguirre, Carolina; Morales Zavala, Francisco; Salas Huenuleo, Edison; Gallardo Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan Bocian, Marcelo (Future Medicine, 2017)
      Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials ...
    • Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide 
      Guerrero, Simon; Araya, Eyleen; Fiedler Temer, Jenny; Arias, J.; Adura, Carolina; Albericio, Fernando; Giralt, Ernest; Arias, José; Fernández, María Soledad; Kogan Bocian, Marcelo (2010)
      Background & aims: Gold nanoparticles (GNPs) have promising applications for drug delivery as well as for the diagnosis and treatment of several pathologies, such as those related to the CNS. However, GNPs are retained in ...
    • Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with ... 
      Bejarano, Julián; Rojas, Aldo; Ramírez Sagredo, Andrea; Riveros Salvatierra, Ana; Morales Zavala, Francisco; Flores, Yvo; Riquelme Meléndez, Jaime; Guzmán, Fanny; Araya, Eyleen; Chiong Lay, Mario; Ocaranza, María Paz; Morales Montecinos, Javier; Villamizar Sarmiento, María Gabriela; Sánchez Vergara, Gina; Lavandero González, Sergio; Kogan, Marcelo J. (Elsevier, 2020)
      Angiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled ...
    • Metal Nanoparticles for the Treatment and Diagnosis of Neurodegenerative Brain Diseases 
      Vio, Valentina; Marchant, María José; Araya, Eyleen; Kogan Bocian, Marcelo (Bentham Science Publishers Ltd., 2017)
      This review focuses on the application of metal nanoparticles in the diagnosis and treatment of Alzheimer's and Parkinson's diseases. Metal nanoparticles present interesting physicochemical properties that can be applied ...
    • Peptide multifunctionalized gold nanorods decrease toxicity of beta-amyloid peptide in a Caenorhabditis ... 
      Morales Zavala, Francisco; Arriagada, Hector; Hassan, Natalia; Velasco, Carolina; Riveros Salvatierra, Ana; Álvarez, Alejandra R.; Minniti, Alicia N.; Rojas Silva, Ximena; Munoz, Luis L.; Vásquez Salfate, Rodrigo; Rodríguez, Katherine; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Aldunate, Rebeca; Kogan Bocian, Marcelo (Elsevier, 2017)
      The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene glycols and ...