Browsing by Author "d58d052b-733c-4d9b-9f6c-11b7c048a941"

Now showing items 1-8 of 8

    • Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old ... 
      Urbina Varela, Rodrigo; Castillo, Nataly; Videla Cabrera, Luis; Campo, Andrea del (MDPI, 2020)
      Mitochondria are the first-line defense of the cell in the presence of stressing processes that can induce mitochondrial dysfunction. Under these conditions, the activation of two axes is accomplished, namely, (i) the ...
    • Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation 
      Campo, Andrea del; Roldán, Juan; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Becerra, Elia; Navarro Márquez, Mario; Mellado, Rosemarie; Lavandero González, Sergio; Corbalán, Ramón; García Nannig, Lorena; Chiong Lay, Mario (Elsevier, 2017)
      Background: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an ...
    • Influence of BDNF Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases 
      Urbina Varela, Rodrigo; Soto Espinoza, María; Vargas, Romina; Quiñones, Luis; Campo, Andrea del (Int Soc Aging & Disease, 2020)
      For the first time in history, most of the population has a life expectancy equal or greater than 60 years. By the year 2050, it is expected that the world population in that age range will reach 2000 million, an increase ...
    • Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance 
      Campo, Andrea del; Bustos, Catalina; Mascayano, Carolina; Acuña Castillo, Claudio; Troncoso, Rodrigo; Rojo, Leonel E. (Frontiers Media SA, 2018)
      Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
    • Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells 
      Bernal Sore, Izela; Navarro Márquez, Mario F.; Osorio Fuentealba, César; Díaz Castro, Francisco; Campo, Andrea del; Donoso Barraza, Camila; Porras Espinoza, Omar; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (Elsevier, 2018)
      Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...
    • Mifepristone for treatment of metabolic syndrome: beyond cushing’s syndrome 
      Díaz Castro, Francisco; Monsalves Álvarez, Matías; Rojo, Leonel E.; Campo, Andrea del; Troncoso, Rodrigo (Frontiers Media, 2020)
      A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
    • Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters 
      Campo, Andrea del; Jaimovich Pérez, Enrique; Tevy, María Florencia (Hindawi, 2016)
      Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in ...
    • Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice 
      Campo, Andrea del; Contreras Hernández, Ignacio Alejandro; Castro Sepúlveda, Mauricio; Campos, Cristian; Figueroa, Reinaldo; Florencia Tevy, María; Eisner, Verónica; Casas Atala, Mariana; Jaimovich Pérez, Enrique (Impact Journals LLC, 2018)
      Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial ...