Browsing by Author "d61f2e62-e083-4d30-8e8a-c8b3ff7fb185"
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Lardone, M. C.; Parada-bustamante, A.; Ebensperger, M.; Valdevenito, R.; Kakarieka, E.; Martínez, D.; Pommer, R.; Piottante, A.; Castro, A. (2011)DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenital (AHC) critical region on the X chromosome gene 1; NR0B1] is an orphan nuclear receptor that acts as a transcriptional repressor in adrenal/gonadal development, ...
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Parada-Bustamante, A.; Molina, C.; Valencia, C.; Flórez, M.; Lardone, M. C.; Argandoña, F.; Piottante, A.; Ebensperguer, M.; Orihuela, P. A.; Castro, A. (Blackwell Publishing Ltd, 2017)© 2017 American Society of Andrology and European Academy of Andrology Estradiol (E2) is normally metabolized to hydroxyestradiols and methoxyestradiols by CYP1A1, CYP1B1 and COMT. However, an altered production of these ...
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Lardone, M. C.; Argandoña, F.; Lorca, M.; Piottante, A.; Palma Ceppi, Cristian; Ebensperger, Mauricio; Castro, A.; Florez, M. (Oxford Univ. Press, 2018-04)STUDY QUESTION: Is the expression of steroidogenic enzyme 17 alpha-Hydroxylase/17,20-Lyase (CYP17A1) down-regulated in Leydig cells (LCs) of men with spermatogenic failure and compensated impairment of LC function, i.e. a ...
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Lardone, M. C.; Argandoña, F.; Flórez, M.; Parada-Bustamante, A.; Ebensperger, M.; Palma, C.; Piottante, A.; Castro, A. (Blackwell Publishing Ltd, 2017)© 2016 American Society of Andrology and European Academy of Andrology Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E2) to T ratio in secretory infertile ...
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P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure Lardone, M. C.; Castillo, P.; Valdevenito, R.; Ebensperger, M.; Ronco Macchiavello, Ana María; Pommer, R.; Piottante, A.; Castro, A. (Blackwell Publishing Ltd, 2010)There is evidence that impaired spermatogenesis is associated with an imbalance in the oestradiol/testosterone ratio and with Leydig cell (LC) dysfunction. In testis, P450-aromatase, encoded by CYP19, is responsible for ...
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Lardone, M. C.; Parodi, D. A.; Valdevenito, R.; Ebensperger, M.; Piottante, A.; Madariaga, M.; Smith, R.; Pommer, R.; Zambrano, N.; Castro, A. (2007)Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this condition. This study investigated ...