Browsing by Author "d76be349-f7db-4d2d-b166-df9e6187b6f6"

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    • Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins 
      Lavaggi, María Laura; Nieves, Marcos; Cabrera, Mauricio; Olea Azar, Claudio; López de Ceráin, Adela; Monge, Antonio; Cerecetto, Hugo; González, Mercedes (2010)
      We have identified phenazine 5,10-dioxides as prodrugs for antitumour therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here, we investigated some structural modifications in order to find new ...
    • Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of ... 
      Lavaggi, María Laura; Cabrera, Mauricio; Aravena, María de los Ángeles; Olea Azar, Claudio; López de Ceráin, Adela; Monge, Antonio; Pachón, Gisela; Cascante, Marta; Bruno, Ana María; Pietrasanta, Lía I.; González, Mercedes; Cerecetto, Hugo (2010)
      Phenazine 5,10-dioxides are prodrugs for antitumor therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here we investigate the expanded system benzo[a]phenazine 7,12-dioxides as selective hypoxic ...