Browsing by Author "dbfb15ca-461f-48dd-a4d6-2ba47b788486"

Now showing items 1-12 of 12

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 
      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the ... 
      Villablanca, Eduardo J.; Pistocchi, Anna; Court, Felipe A.; Cotelli, Franco; Bordignon, Claudio; Allende Connelly, Miguel; Traversari, Catia; Russo, Vincenzo (American Association of Immunologists, 2007)
      PGE2 is involved in a wide variety of physiological and pathological processes; however, deciphering its role in early mammalian development has been difficult due to the maternal contribution of PGE 2. To overcome this ...
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 
      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Bursting the unfolded protein response accelerates axonal regeneration 
      Oñate, Maritza; Court, Felipe A.; Hetz Flores, Claudio (Medknow Publications, 2016)
    • Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile 
      Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Oñate, Maritza G.; Martínez Bravo, Gabriela; Catenaccio, Alejandra; Wishart, Thomas M.; Court, Felipe A. (Springer, 2020)
      Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by ...
    • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model 
      Bargsted, Leslie; Medinas Bilches, Danilo; Martínez Traub, Francisca; Rozas, Pablo; Muñoz, Natalia; Nassif, Melissa; Jerez, Carolina; Catenaccio, Alejandra; Court, Felipe A.; Hetz Flores, Claudio; Matus, Soledad (Nature Publishing Group, 2017)
      Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
    • GERO cohort protocol, Chile, 2017–2022: community-based cohort of functional decline in subjective cognitive ... 
      Slachevsky Chonchol, Andrea; Zitko, Pedro; Martínez Pernía, David; Forno, Gonzalo; Court, Felipe A.; Lillo, Patricia; Villagra Castro, Roque; Durán Aniotz, Claudia Andrea; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibáñez, Agustín; Parra, Mario A.; González Billault, Christian; Amieva, Helena; Thumala, Daniela (BMC, 2020)
      Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly ...
    • Injury to the nervous system: A look into the ER 
      Valenzuela, Vicente; Oñate, Maritza; Hetz Flores, Claudio; Court, Felipe A. (Elsevier B.V., 2016)
      © 2016 Elsevier B.V.Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves ...
    • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal ... 
      García Huerta, Paula; Troncoso Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas, Marisol; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez Billault, Christian; Bergink, Steven; Vidal, René L.; Hetz Flores, Claudio (Springer, 2020)
      Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Mitochondria and calcium regulation as basis of neurodegeneration associated with aging 
      Müller, Marioly; Ahumada-Castro, Ulises; Sanhueza, Mario; González Billault, Christian; Court, Felipe A.; Cárdenas, César (Frontiers Media S.A., 2018)
      © 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
    • The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease 
      Oñate, Maritza; Catenaccio, Alejandra; Salvadores, Natalia; Saquel, Cristian; Martínez Rojas, Luis; Moreno González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz Flores, Claudio; Court, Felipe A. (Nature Publishing Group, 2020)