Browsing by Author "dc961bbd-2051-4dc6-865a-23c19b3488e1"

Now showing items 1-5 of 5

    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ ... 
      Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Endoplasmic reticulum mitochondria calcium communication and the regulation of mitochondrial metabolism in ... 
      Bustos, Galdo; Cruz, Pablo; Lovy, Alenka; Cárdenas Matus, Julio (Frontiers media SA, 2017)
      Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to ...
    • InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer 
      Lovy, Alenka; Foskett, J. Kevin; Cárdenas, César (Taylor & Francis, 2016-06)
      Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca2+ transfer to mitochondria as an unexpected requirement for ...
    • MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: ... 
      Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka; Pardo, Evelyn; Molgό, Jordi; Cárdenas, César (Taylor and Francis Inc., 2019)
      © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent ...
    • Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria 
      Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaňa, Fabian; Bustos, Galdo; Urra, Felix; Smith, Natalia; Molgó, Jordi; Diehl, J. Alan; Ridky, Todd W.; Foskett, J. Kevin (Elsevier B.V., 2016)
      © 2016 The Authors.In the absence of low-level ER-to-mitochondrial Ca2+ transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we ...