Browsing by Author "dce2736d-599e-41c6-92b0-77563039ba87"

Now showing items 1-3 of 3

    • Cyclin - dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C - ... 
      Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2017)
      The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size ...
    • Targeted overexpression of tumor necrosis factor-a increases cyclin-dependent kinase 5 activity and ... 
      Rozas, Pablo; Lazcano, Pablo; Piña, Ricardo; Cho, A.; Terse, Anita; Pertusa, María; Madrid, Rodolfo; González Billault, Christian; Kulkarni, Ashok B.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2016)
      We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
    • TNF-α increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons 
      Sandoval Guzmán, Rodrigo; Lazcano Sánchez, Pablo; Ferrari Soto, Franco; Pinto Pardo, Nicolás; González Billault, Christian; Utreras Puratich, Elías (Frontiers Media, 2018)
      The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...