Browsing by Author "e505c28c-84a5-4818-815c-f0af29c9480d"

Now showing items 1-10 of 10

    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ ... 
      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside 
      Palacios, Miriam; Tampe, Ricardo; Campo, Miguel del; Zhong, Ta-Ying; López, Mercedes N.; Salazar Onfray, Flavio; Becker, María Inés (Elsevier, 2018-04-25)
      Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
    • Interleukin 10 decreases MICA expression on melanoma cell surface 
      Serrano, Antonio E.; Menares Castillo, Evelyn; Garrido Tapia, Macarena; Hager Ribeiro, Carolina; Hernández, Carolina J.; Mendoza Naranjo, Ariadna; Gatica Andrades, Marcela; Valenzuela Díaz, Rodrigo; Zúñiga, Roberto; López, Mercedes N.; Salazar Onfray, Flavio; Aguillón, Juan Carlos (2011)
      Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC) class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...
    • Inverse relationship between alzheimer's disease and cancer: How immune checkpoints might explain the ... 
      Rogers Castillo, Nicole K.; Romero, César A.; San Martín Rovirosa, Carol D.; Ponce, Daniela P.; Salech Morales, Felipe; López, Mercedes N; Gleisner, Alejandra; Tempio Sepúlveda, Fabián; Behrens Pellegrino, María I. (IOS Press, 2020)
      Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the adult population. There is evidence of an inverse epidemiological relationship between AD and cancer, another prevalent age-related disease. ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for ... 
      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...
    • Molluskan hemocyanins activate the classical pathway of the human complement system through natural antibodies 
      Pizarro Bauerle, Javier; Maldonado, Ismael; Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; López, Mercedes N.; Salazar Onfray, Flavio; Aguilar Guzmán, Lorena Andrea; Valck Calderón, Carolina Eliana; Ferreira, Arturo; Becker, María Inés (Frontiers Research Foundation, 2017)
      © 2017 Pizarro-Bauerle, Maldonado, Sosoniuk-Roche, Vallejos, López, Salazar-Onfray, Aguilar-Guzmán, Valck, Ferreira and Becker. Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable ...
    • Prolonged survival of dendritic cell-vaccinated melanoma patients correlates with tumor-specific delayed ... 
      López, Mercedes N.; Pereda, Cristian; Segal, Gabriela; Muñoz, Leonel; Aguilera, Raquel; González, Fermín E.; Escobar, Alejandro; Ginesta, Alexandra; Reyes, Diego; González, Rodrigo; Mendoza Naranjo, Ariadna; Larrondo, Milton; Compán, Alvaro; Ferrada, Carlos; Salazar Onfray, Flavio (2009)
      Purpose The aim of this work was to assess immunologic response, disease progression, and posttreatment survival of melanoma patients vaccinated with autologous dendritic cells (DCs) pulsed with a novel allogeneic cell ...
    • Pure platelet-rich plasma and supernatant of calcium-activated P-PRP induce different phenotypes of human ... 
      Escobar, Gisselle; Escobar Álvarez, Alejandro; Ascui, Gabriel; Tempio, Fabián I.; Ortiz, María C.; Pérez Núñez, Claudio; López, Mercedes N. (Future Medicine, 2018)
      Aim: This study aimed to evaluate the effect of two platelet preparations used in the clinic, pure platelet-rich plasma (P-PRP) and the supernatant of calcium-activated P-PRP (S-PRP), on the phenotype of human macrophages. ...
    • TAPcells, the Chilean dendritic cell vaccine against melanoma and prostate cancer 
      Salazar Onfray, Flavio; Pereda, Cristián; Reyes, Diego; López, Mercedes N. (2013)
      Here we summarize 10 years of effort in the development of a biomedical innovation with global projections. This innovation consists of a novel method for the production of therapeutic dendritic-like cells called Tumor ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes ... 
      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...