Browsing by Author "e78862b7-bde2-43a0-ad0d-90428b76a31b"
Now showing items 1-16 of 16
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Ledezma, Rodrigo; Cifuentes, Federico; Gallegos, Iván; Fullá, Juan; Ossandon, Enrique; Castellon, Enrique A.; Contreras, Héctor R. (2011)The clinical features of prostate cancer do not provide an accurate determination of patients undergoing biochemical relapse and are therefore not suitable as indicators of prognosis for recurrence. New molecular markers ...
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Cifuentes, Federico F.; Valenzuela, Rodrigo H.; Contreras, Héctor R.; Castellón, Enrique A. (Spandidos Publications, 2015)© 2015, Spandidos Publications. All rights reserved. Prostate cancer is one of the most prevalent oncological diseases in males worldwide, and the mortalities resulting from this type of cancer are mainly due to metastasis. ...
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Castellón Vera, Enrique; Clementi, Marisa; Hitchsfeld, Catalina; Sánchez, Catherine; Benítez, Dixan; Sáenz Iturriaga, Leonardo Enrique; Contreras, Héctor R.; Huidobro Alvarado, Christian (TAYLOR & FRANCIS INC, 2006-05)Contradictory data have been reported regarding the effect of GnRH agonists and antagonists on cell growth and survival, using prostate cancer-derived cell lines expressing either endogenous or exogenous GnRH receptors. ...
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Escalante Escalante, Paula; Quiñones, Luis Abel; Contreras, Héctor R. (MDPI, 2021)The FOLFOX scheme, based on the association of 5-fluorouracil and oxaliplatin, is the most frequently indicated chemotherapy scheme for patients diagnosed with metastatic colorectal cancer. Nevertheless, development of ...
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Evaluation of MENT on primary cell cultures from benign prostatic hyperplasia and prostate carcinoma Mendoza, Patricia; Sánchez, Catherine; Contreras, Héctor R.; Vergara, Jorge; Acevedo Castillo, Cristián; Cabezas Castillo, Juan; Huidobro Alvarado, Christian; Noé, Gabriela; Castellón Vera, Enrique (Blackwell, 2008)7-alpha-Methyl-19-Nortestosterone (MENT) is a synthetic androgen more potent than testosterone (T) and cannot be reduced at 5-alpha position. No important effects of MENT on prostate growth have been reported. However, little ...
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Sánchez, Catherine; Mendoza, Patricia; Contreras, Héctor R.; Vergara, Jorge; McCubrey, James A.; Huidobro, Christian; Castellón, Enrique A. (2009)BACKGROUND. Multidrug resistance (MDR) proteins have been associated with the lack of chemotherapy response. Expression of these proteins has been described in the prostate, but there is no information about their role in ...
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Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer Castillo, Viviana; Valenzuela, Rodrigo; Huidobro Alvarado, Christian; Contreras, Héctor R.; Castellón, Enrique A. (Spandidos, 2014)Cancer stem cells (CSCs) have the ability to self-renew and differentiate to give rise to heterogeneous phenotype of the tumor cells. It is believed that these cells are involved in metastasis, recurrence and therapy ...
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Clementi, Marisa; Sánchez, Catherine; Benítez, Dixan A.; Contreras, Héctor R.; Huidobro, Christian; Cabezas, Juan; Acevedo, Cristian; Castellón, Enrique A. (Wiley, 2009)BACKGROUND. Gonadotropin-releasing-hormone (GnRH) analogs are widely used to block hypothalamic–pituitary–gonadal axis and inhibit blood androgen levels in patients with prostate cancer (PCa). In addition, GnRH analogs ...
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Contreras, Héctor R.; García, Carlos (Taylor and Francis Ltd., 2019)Okadaic acid group (OA-group) is a set of lipophilic toxins which are characterised by being produced by species associated with the genera Dinophysis and Prorocentrum. OA-group has been regularly detected in endemic ...
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Castellón, Enrique A.; Valenzuela, Rodrigo; Lillo, Jorge; Castillo, Viviana; Contreras, Héctor R.; Gallegos, Iván; Mercado, Alejandro; Huidobro, Christian (2012)Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Chemotherapy response is very poor and resistance to hormone-based treatments is frequent in advances stages. Recently, tumor-initiating ...
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Sánchez, Catherine A.; Mercado, Alejandro J.; Contreras, Héctor R.; Cabezas, Juan C.; Huidobro, Christian C.; Castellón, Enrique A. (2012)Gonadotropin-releasing hormone (GnRH) agonists are widely used for the treatment of advanced prostate cancer (PCa). Agonists activate the GnRH receptor (GnRH-R), triggering apoptosis in PCa cells. In gonadotropes, the ...
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García, Carlos; Pérez, Francisco; Contreras, Cristóbal; Figueroa, Diego; Barriga, Andrés; López-Rivera, Américo; Araneda, Oscar F.; Contreras, Héctor R. (Taylor and Francis Ltd., 2015)© 2015, © 2015 Taylor & Francis. Harmful algae blooms (HABs) are the main source of marine toxins in the aquatic environment surrounding the austral fjords in Chile. Huichas Island (Aysén) has an history of HABs spanning ...
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Castellón Vera, Enrique; Venegas, Karina; Sáenz Iturriaga, Leonardo Enrique; Contreras, Héctor; Huidobro Alvarado, Christian (2005)We investigate the proliferative activity, prostatic specific antigen (PSA) secretion, morphology and androgen response of human prostate tumour epithelial cells co-cultured with stromal cells in a bicameral system. ...
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Contreras, Héctor R. (2010)Syndecans, a family of heparan sulphate proteoglycans that are present in the cell surface are involved in the control of cell proliferation, apoptosis and transformation. Syndecans 1 and 2 have a central role in processes ...
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García, Carlos; Oyaneder Terrazas, Javiera; Figueroa, Diego; Díaz, Carolina; Mora, Romina; Contreras, Héctor R. (Nova Science, 2017)For years, marine resources have been an important part of human development due to the high nutritional contribution they possess. Mussels sp. are the most consumed species in the world. As a result of requirements and ...
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Farfán, Nancy; Ocarez, Nallatt; Castellón Vera, Enrique; Mejía, Nilo; García de Herreros, Antonio; Contreras, Héctor R. (Nature, 2018)Syndecan 1 (SDC-1) is a cell surface proteoglycan with a significant role in cell adhesion, maintaining epithelial integrity. SDC1 expression is inversely related to aggressiveness in prostate cancer (PCa). During epithelial ...