Browsing by Author "e8204253-cb1f-4d88-83ae-56b1086f2eb2"

Now showing items 1-6 of 6

    • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome ... 
      Kim, Soo Young; Zhang, Xin; Schiattarella, Gabriele G.; Altamirano, Francisco; Ramos, Thais; French, Kristin M.; Jiang, Nan; Szweda, Pamela A.; Evers, Bret M.; May, Herman; Luo, Xiang; Li, Hongliang; Szweda, Luke; Maracajá Coutinho, Vinicius; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2020)
      BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
    • FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth 
      Ferdous, Anwarul; Wang, Zhao V.; Luo, Yuxuan; Li, Dan L.; Luo, Xiang; Schiattarella, Gabriele G.; Altamirano, Francisco; May, Herman I.; Battiprolu, Pavan K.; Nguyen, Annie; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2020)
      Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
    • Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AK ... 
      Córdova, Andrés; Olmedo, Ivonne; Riquelme, J.; Barrientos, G.; Sánchez, G.; Gillette, Thomas G.; Lavandero González, Sergio; Chiong Lay, Mario; Donoso, P.; Pedrozo Cibils, Zully (Elsevier Science BV, 2018)
      The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
    • Metabolic stress - Induced activation of FoxO1 triggers diabetic cardiomyopathy in mice 
      Battiprolu, Pavan K.; Hojayev, Berdymammet; Jiang, Nan; Wang, Zhao V.; Luo, Xiang; Iglewski, Myriam; Shelton, John M.; Gerard, Robert D.; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (2012)
      The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary disease. However, ...
    • Nitrosative stress drives heart failure with preserved ejection fraction 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Tong, Dan; French, Kristin M.; Villalobos, Elisa; Kim, Soo Young; Luo, Xiang; Jiang, Nan; May, Herman I.; Wang, Zhao V.; Hill, Theodore M.; Mammen, Pradeep; Huang, Jian; Lee, Dong I.; Hahn, Virginia; Sharma, Kavita; Kass, David A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature Publishing Group, 2019)
      Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive ...
    • Polycystin-2-dependent control of cardiomyocyte autophagy 
      Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...